THE EFFECT OF GARLIC EXTRACT ADMINISTRATION ON THE PROFILE OF ERYTHROCYTES AVERAGE NUMBER IN MICE INFECTED WITH TRYPANOSOMA EVANSI

Abstract

The aim of this study was to determine the effect of garlic extract administration on the profile of erythrocytes average number in mice infected with Trypanosoma evansi. T. evansi was isolated from surra cases in Buntok, South Kalimantan in 2019, and garlic was extracted by maceration method. The samples of this research used 30 male mice from the Deutch Democratic Yokohama strain with 25-30 grams body weight and grouped into 6 treatments. Each treatment consisted of 5 mice, 4 groups of it which were infected with T. evansi injected by intraperitoneal route. The results of the erythrocyte's average number showed the group of mice without treatment (K0) was 8.92±0.41 x106/?l at the beginning and 8.31±0.63 x106/?l at the end of the study. In the group of mice infected with T. evansi without treatment (K1) the average number of erythrocytes before infection was 8.20±1.01 x106/?l and 6.35±3.91 x106/?l after infection. The average number of erythrocytes in the group of mice infected with T. evansi and administered trypanosidal (K2) before infection was 8.44±1.27 x106/?l and 7.02±2.78 x106/?l after infected. The treatment of the mice group with garlic extract doses,  50 mg/kg BW (K3), 100 mg/kg BW (K4), 200 mg/kg BW (K5), before infected with T. evansi, the erythrocytes average number was 7.92±0.54 x106/?l, 7.88±0.09 x106/?l, 8.41±0.93 x106/?l, and 7.34±4.35 x106/?l, 5.85±1.53 x106/?l, 6.79±1.18 x106/?l after infected. Based on the results, concluded that there was no significant difference in the administration of garlic extract with the profile of erythrocytes average number in mice infected with T. evansi. Therefore, it is necessary to conduct further studies and research on other parameters such as the form of cell morphometric measurements and the average number of other cells such as leukocytes and platelets.