PLATELET COUNT AND MEAN PLATELET VALUE OF RABBIT IMPLANTED BALI CATTLE BONE GRAFT

  • Steven Dwi Purbantoro DVM Student of The Faculty Veterinary Medicine, Udayana University, Jl. PB. Sudirman, Denpasar, Bali, Indonesia, 80234
  • I Wayan Wirata Laboratory of Veterinary Surgery, Faculty of Veterinary Medicine, Udayana University, Jl. Sesetan Gg. Markisa No 6, Denpasar, Bali, Indonesia, 80234
  • Komang Darma Yudha Putra DVM Student of The Faculty Veterinary Medicine, Udayana University, Jl. PB. Sudirman, Denpasar, Bali, Indonesia, 80234

Abstract

Platelets play an important role in fracture healing. However, its role is still underappreciated. Therefore, this study investigated the values of mean platelet volume (MPV) and platelet count (PC) as the parameters in fracture healing. This study used 10 male local rabbits which were divided into 2 groups randomly, KI (control group) and KII (treatment group). Each femur of both groups was drilled a hole with a diameter of 5 mm, where KI without any substitutes and KII was implanted by demineralized bali cattle bone graft. Each animal was evaluated by collecting its blood from the central auricular vein into an EDTA tube at 24 hours, week 2, 4, and 6 postoperative determining the values of MPV and PC. Results show that treatment shows no differences to MPV and PC, yet time observation does. Overall, MPV and PC were increased in number during observation and are correlated positively.

Downloads

Download data is not yet available.

Author Biography

Komang Darma Yudha Putra, DVM Student of The Faculty Veterinary Medicine, Udayana University, Jl. PB. Sudirman, Denpasar, Bali, Indonesia, 80234

Student of Veterinary Medicine Faculty

References

Ali RA, Wuescher LM, Worth RG. 2015. Platelets: essential components of the immune system. Curr. Trends. Immunol. 16: 65-78.
Arslan HH, Guzel M, Meral Y, Dalgin D, Gokalp G, Ozcan U. 2017. A new approach to blood parameters in dogs with hemorrhagic enteritis. Acta Sci. Vet. 45: 1458.
Barnes GL, Kostenuik PJ, Gerstenfeld LC, Einhorn TA. 1999. Growth factor regulation of fracture repair. J. Bone Mineral Res. 14: 1805-1815.
Gruber R, Varga F, Fischer MB, Watzek G. 2002. Platelets stimulate proliferation of bone cells: involvement of platelet-derived growth factor, microparticles and membranes. Clin. Oral. Impl. Res. 13: 529-535.
Joyce ME, Roberts AB, Sporn MB, Bolander ME. 1990. Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur. J. Cell Biol. 110: 2195-2207.
Kark LR, Karp JM, Davies JE. 2006. Platelet releasate increases the proliferation and migration of bone marrow-derived cells culture under osteogenic conditions. Clin. Oral Impl. Res. 17: 321-327.
Mayda-Domac F, Misirli H, Yilmaz M. 2010. Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. J. Stroke Cardiovascular Dis. 19(1): 66-72.
Noris P, Melazzini F, Balduini CL. 2016. New roles for mean platelet volume measurement in the clinical practice?. Platelets Early Online: 1-6.
Ocak T, Erdem A, Duran A, Tekelioglu U, Ozturk S, Ayhan S, Ozlu FM, Yazici M. 2013. The importance of the mean platelet volume in the diagnosis of supraventricular tachycardia. African Health Sci. 13(3): 590-594.
Sharif PS, Abdollahi M. 2010. The Role of Platelets in bone remodeling. Inflammation & Allergy – Drug Targets 9: 393-399.
Wagner DD, Burger PC. 2003. Platelets in inflammation and thrombosis. Arterioscler Thromb. Vasc. Biol. 23: 2131-2137.
Weiss DJ, Wardrop KJ. 2010. Schalm’s Veterinary Hematology. 6th Ed. USA: Blackwell Publishing.
Wirata IW, Purbantoro SD, Sudimartini LM, Gunawan IWNF, Dharmayudha AAO, Pemayun IGAGP. 2018. Radiographic evaluation of rabbit femur implanted bali cattle bone graft. J. Vet. 19(3): 439-445.
Published
2022-01-29
How to Cite
PURBANTORO, Steven Dwi; WIRATA, I Wayan; PUTRA, Komang Darma Yudha. PLATELET COUNT AND MEAN PLATELET VALUE OF RABBIT IMPLANTED BALI CATTLE BONE GRAFT. Buletin Veteriner Udayana, [S.l.], p. 333-337, jan. 2022. ISSN 2477-2712. Available at: <https://ojs.unud.ac.id/index.php/buletinvet/article/view/51565>. Date accessed: 23 apr. 2024. doi: https://doi.org/10.24843/bulvet.2022.v14.i04.p03.
Section
Articles