RECENT DEVELOPMENT IN INVESTIGATION OF CHICKEN LEPTIN GENE: A REVIEW

  • I Wayan Swarautama Mahardhika Gama Ayam Research Team, Laboratory of Genetics and Breeding, Faculty of Biology, Universitas Gadjah Mada. Jl. Teknika Selatan, Sinduadi, Mlati, Kabupaten Sleman, Daerah Istimewa Yogyakarta 55281
  • Budi Setiadi Daryono Gama Ayam Research Team, Laboratory of Genetics and Breeding, Faculty of Biology, Universitas Gadjah Mada. Jl. Teknika Selatan, Sinduadi, Mlati, Kabupaten Sleman, Daerah Istimewa Yogyakarta 55281

Abstract

The leptin coding gene (LEP) investigation in several avian species has been carried out in-depth for over 20 years. Genomic expression of LEP gene in numbers of avian species has been identified, including Falco peregrinus and Falco cherrug, Pseudopodoces humilis, Taeniopygia guttata, Columba livia, Haliaeetus leucocephalus, Picoides pubescens, and Melopsittacus undulatus. However, molecular genetics identification of LEP gene expression in chicken (G. g. gallus) is still debated. The Indonesian indigenous chicken poultry industry is growing rapidly, with some limitations, one of which involves Indonesian indigenous chicken's productivity. Indonesian indigenous chicken contributes 23% of national food consumption annually. Increased productivity of Indonesian indigenous chicken can be achieved through selective breeding. Selective breeding seeks to improve the genetic quality of Indonesian indigenous chicken by empowering Indonesian indigenous chicken germplasm. Selective breeding allows the production of meat-type and layer-type hybrids with superior characteristics following the design of the specified crossing pattern. Selective breeding requires both Mendelian and molecular genetics as guidance and evaluation methods to maintain breeding direction effectiveness. Several identified genes that have a significant implication on chicken productivity have been researched thoroughly. However, several other important gene candidates, including the LEP gene, still require in-depth research. This review integrates several studies on the chicken LEP gene from the initial discovery until the latest breakthrough.

Downloads

Download data is not yet available.

References

Abbasi HA, Gharavysi S, Abdullahpour R. 2011. Genetic polymorphism exon 9-11 at the Leptin gene receptor in breeder hens of Mazandaran native fowls. J. Anim. Vet. Adv. 10(21): 2802-2805.
Adachi H, Takemoto Y, Bungo T, Ohkubo T. 2008. Chicken leptin receptor is functional in activating JAK-STAT pathway in vitro. J. Endocrinol. 197:335–342.
Adachi H, Murase D, Atomura S, Ohkubo T. 2012. Detection of leptin activity in living cells expressing chicken leptin receptor and STAT3. J. Poult. Sci. 49: 46-50.
Al-Nasser A, Al-Khalaifa H, Al-Saffar A, Khalil F, Al-Bahouh M, Ragheb G, Al-Haddad A, Mashaly M. 2007. Overview of chicken taxonomy and domestication. World’s Poult. Sci. J. 63(2): 285–300.
Amills M, Jimenez N, Villalba D, Tor M, Molina E, Cubilo D, Marcos C, Francesch A, Sanchez A, Estany J. 2003. Identification of three single nucleotide polymorphisms in the chicken insulin-like growth factor 1 and 2 genes and their associations with growth and feeding traits. Poult. Sci. 82: 1485–1493.
Anggitasari S, Sjofjan O, Djunaidi IH. 2016. Pengaruh beberapa jenis pakan komersial terhadap kinerja produksi kuantitatif dan kualitatif ayam pedaging. Buletin Peternakan. 40(3): 187-196.
Ashwell CM, Czerwinski SM, Brocht DM, McMurtry JP. 1999. Hormonal regulation of leptin expression in Broiler chickens. Am. J. Physiol. 276: R226–R232.
Bamidele O, As P Van, Elferink MG. 2012. Molecular characterization of the leptin receptor gene as a candidate gene in the pulmonary hypertension syndrome in broiler chickens. Pak. J. Biol. Sci. 15(24): 1187-1190.
Buchanan FC, Fitzsimmons CJ, Van Kessel AG, Thue TD, Inkelman-Sim DC, Schmutz SM. 2002. Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels. Genet. Select. Evol. 34: 105-116.
Chen HY, Trumbauer ME, Chen AS, Weingarth DT, Adams JR, Frazier EG, Shen Z, Marsh DJ, Feighner SD, Guan XM, Ye Z, Nargund RP, Smith RG, Van der ploeg LH, Howard AD, MacNeil DJ, Qian S. 2004. Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinol. 145(6): 2607–2612.
Dai HC, Long LQ, Zhang XW, Zhang WM, Wu XX. 2007. Cloning and expression of the duck leptin gene and the effect of leptin on food intake and fatty deposition in mice. Asian-Australasian J. Anim. Sci. 20(6): 850–55.
Daryono BS, Roosdianto I, Saragih HTS. 2010. Pewarisan Karakter Fenotip Ayam Hasil Persilangan Ayam Pelung dengan Ayam Cemani. J. Vet. 11(4): 257-263.
de Verdal H, Narcy A, Bastianelli D, Chapuis H, Même N, Urvoix S, Le Biham-Duval E, Mignon-Grasteau S. 2011. Improving the efficiency of feed utilization in poultry by selection. 1. Genetic parameters of anatomy of the gastro-intestinal tract and digestive efficiency. BMC. Genet. 12: 59.
Dunn IC, Boswell T, Friedman-Einat M, Eshdat Y, Burt DW, Paton IR. 2000. Mapping of the leptin receptor gene (LEPR) to chicken chromosome 8. Anim. Genet. 31: 290.
Dunn IC, Girishvarma G, Talbot RT, Waddington D, Boswell T, Sharp PJ. 2001. Evidence for low homology between the chicken and mammalian leptin genes. In: Avian Endocrinology (Dawson A and Chaturvedi CM eds.). Narosa Publishing House. New Delhi.
El-Moujahid EM, Chen S, Jin S, Lu Y. 2014. Association of leptin receptor gene polymorphisms with growth and feed efficiency in meat-type chickens. Poult. Sci. 93: 1910–1915.
Ferket PR, Gernat AG. 2006. Factors that affect feed intake of meat birds: A review. Int. J. Poult. Sci. 5: 905–911.
Friedman-Einat M, Boswell T, Horev G, Girishvarma G, Dunn IC, Talbot RT, Sharp PJ. 1999. The chicken leptin gene: has it been cloned? Gen. Comp. Endocrinol. 115: 354–363.
Frühbeck G, Gomez-Ambrosi J, Salvador J. 2001. Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes. FASEB J. 15: 333-340.
Gautron L, Elmquist JK. 2011. Sixteen years and counting: an update on leptin in energy balance. J.Clin. Invest. 121: 2087-2093.
Gurriaran-Rodriguez U, Al-Massadi O, Crujeiras AB, Mosteiro CS, Amil-Diz M, Beiroa D et al., 2011. Preproghrelin expression is a key target for insulin action on adipogenesis. J. Endocrinol. 210: R1-7.
Harvey J, Ashford ML. 2003. Leptin in the CNS: Much More than A Satiety Signal. Neuropharmacology 44: 845-854.
Hen G, Yosefi S, Ronin A, Einat P, Rosenblum CI, Denver RJ, Friedman-Einat. 2008. Monitoring leptin activity using the chicken leptin receptor. J. Endocrinol. 197: 325–333.
Henuk, YL, Bailey CA. 2014. Husbandry systems for native chickens in Indonesia. In: Proc. of the 16th AAAP Animal Science Congress. Yogyakarta (Indones): Universitas Gadjah Mada. Pp. 759–762.
Horev G, Einat P, Aharoni T, Eshdat Y, Friedman-Einat M. 2000. Molecular cloning and properties of the chicken leptin-receptor (CLEPR) gene. Mol. Cell. Endocrinol. 162: 95–106.
Hossner KL. 1998. Cellular, molecular and physiological aspects of leptin: Potential application in animal production. Can. J. Anim. Sci. 78: 463–472.
Klok MD, Jakobsdottir S, Drent ML. 2007. The Role of Leptin and Ghrelin in the Regulation of Food Intake and Body Weight in Humans: A Review. Obes. Rev. 8(1): 21–34.
Liefers SC, te Pas MF, Veerkamp RF, Van Der Lende T. 2002. Associations between leptin gene polymorphisms and production, live weight, energy balance, feed intake and fertility in Holstein heifers. J. Dairy. Sci. 85: 1633-1638.
Liu X, Dunn IC, Sharp PJ, Boswell T. 2007. Molecular cloning and tissue distribution of a short form chicken leptin receptor mRNA. Domest. Anim. Endocrinol. 32: 155–166.
Mrázová Ľ, Angelovi M, Král M. 2012. Monitoring the expression of leptin receptor in avian model. Anim. Sci. Biotech. 45(1): 322–327.
Nataamijaya AG. 2010. Pengembangan potensi ayam lokal untuk menunjang peningkatan kesejahteraan petani. J. Litbang Pertanian. 29(4): 131-133.
Ningsih R, Prabowo DW. 2017. Tingkat integrasi pasar ayam broiler di sentra produksi utama: studi kasus Jawa Timur dan Jawa Barat. Buletin Ilmiah Litbang Perdagangan. 11(2): 247-270
Ninov K, Ledur MC, Alves HJ, do Rosário MF, Nones K, Coutinho LL. 2008. Investigation of Leptin gene in Broiler and Layer chicken lines. Sci. Agric. 65(2): 214–219.
Niv-Spector L, Raver N, Friedman-Einat M, Grosclaude J, Gussakovsky EE, Livnah O, Gertler A. 2005. Mapping leptin-interacting sites in recombinant leptin-binding domain (LBD) subcloned from chicken leptin receptor. Biochem. J. 390: 475–484
Nkrumah JD, Li C, Yu J, Hansen C, Keisler DH, Moore SS. 2005. Polymorphisms in the bovine leptin promoter associated with serum leptin concentration, growth, feed intake, feeding behavior, and measures of carcass merit. J. Anim. Sci. 83: 20-28.
Nurfadillah S, Rachmina D, Kusnadi N. 2018. Impact of trade liberization on Indonesian broiler competitiveness. J. Indonesian Trop. Anim. Agric. 43(4): 429-437.
Ohkubo T, Adachi H. 2008. Leptin signaling and action in birds. J. Poult. Sci. 45: 269-273.
Ohkubo T, Nishio M, Tsurudome M, Ito M, Ito Y.2007. Existence of leptin receptor protein in chicken tissues: isolation of a monoclonal antibody against chicken leptin receptor. Gen. Comp. Endocrinol. 151: 269-273.
Ohkubo T, Tanaka M, Nakashima K. 2000. Structure and tissue distribution of chicken leptin receptor (cOb-R) mRNA. Biochim. Biophysica Acta. 1491: 303-308.
Ohkubo T. 2014. Recent Progress in Avian Leptin Research Recent Progress in Avian Leptin Research. J. Poult. Sci. 51: 343-351.
Paczoska-Eliasiewicz HE, Gertler A, Proszkowiec M, Proudman J, Hrabia A, Sechman A, Rzasa J. 2003. Attenuation by leptin of the effects of fasting on ovarian function in hens (Gallus domesticus). Reprod. 126(6): 739–751.
Pitel F, Bergé R, Coquerelle G, Crooijmans RPMA, Groenen MAM, Vignal A, Tixier-Boichard M. 2000. Mapping the naked neck (NA) and polydactyly (PO) mutants of the chicken with microsatellite molecular markers. Genet. Sel. Evol. 32: 73–86.
Pitel F, Monbrun C, Gellin J, Vignal A. 1999. Mapping of the LEP (OB) gene to a chicken microchromosome. Anim. Genet. 30: 73-74
Pusat Pengkajian Perdagangan Dalam Negeri. 2018. Jakarta (Indones): Kementerian Perdagangan RI. p. 52-66
Richards MP, Poch SM. 2003. Molecular cloning and expression of the turkey leptin receptor gene. Com. Biochem. Physiol. B Biochem. Mol. Biol. 136: 833-847.
Robert C, Palin MF, Coulombe N, Roberge C, Silversides FG, Benkel BF, McKay RM, Pelletier G. 1998. Backfat thickness in pigs is positively associated with leptin mRNA levels. Can. J. Anim. Sci. 78: 473–482
Rodriguez A, Becerril S, Valenti V, Moncada R, Mendez-Gimenez L, Ramirez B. 2011. Short-term Effects of sleeve gastrectomy and caloric restriction on blood pressure in diet-induced obese rats. Obes. Surg. 22: 1481-1490.
Rodriguez A, Catalan V, Gomez-Ambrosi J, Garcia-Navarro S, Rotellar F, Valenti V. 2011b. Insulin and leptin mediated control of aquaglyceroporins in human adipocytes and hepatocytse is mediated via the PI3K/Akt/mTOR signaling cascade. J. Clin. Endocrinol. Metab. 96: E586-597.
Rodriguez A, Catalan V, Gomez-Ambrosi J. and Frühbeck G. 2011a. Aquaglyceroporins serve as metabolic gateways in adiposity and insulin resistance control. Cell Cycle. 10: 1548-1556.
Rodríguez, A. 2014. Novel molecular aspects of ghrelin and leptin in the control of adipobiology and the cardiovascular system. Obesity Facts. 7(2): 82–95.
Seroussi E, Cinnamon Y, Yosefi S, Genin O, Smith JG, Rafati N, Friedman-Einat M. 2016. Identification of the long-sought leptin in chicken and duck: Expression pattern of the highly GC-rich avian leptin fits an autocrine/paracrine rather than endocrine function. Endocrinol. 157(2): 737–751.
Seroussi E, Pitel F, Leroux S, Morisson M, Bornelöv S, Miyara S, Friedman-Einat M. 2017. Correction: Mapping of leptin and its syntenic genes to chicken chromosome 1p. BMC Genet. 18(1): 1–8.
Tachibana T, Tsutsui K. 2016. Neuropeptide control of feeding behavior in birds and its difference with mammals. Front. Neurosci. 10: 1–13.
Tangendjaja B. 2007. Inovasi teknologi pakan menuju kemandirian usaha ternak unggas. Wartazoa. 17(1): 12-20
Taniguchi Y, Itoh T, Yamada T, Sasaki Y. 2002. Genomic structure and promoter analysis of the bovine leptin gene. IUBMB Life. 53: 131-135.
Taouis M, Chen JW, Daviaud C, Dupont J, Derouet M, Simon J. 1998. Cloning the chicken leptin gene. Gene 208: 239-242.
Toshinai K, Date Y, Murakami N, Shimada M, Mondal MS, Shimbara T. 2003. Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinol. 144: 1506–1512.
Walker CG, Holness MJ, Gibbons GF, Sugden MC. 2007. Fasting induced increases in aquaporin 7 and adipose triglyceride lipase mRNA expression in adipose tissue are attenuated by peroxisome proliferator-activated receptor alpha deficiency. Int. J. Obes. 31: 1165-1171
Wang F, Lu L, Yuan H, Tian Y, Li J, Shen J, Tao Z, Fu Y. 2011. Molecular cloning, expression, and regulation of goose leptin receptor gene in adipocytes. Mol. Cell. Biochem. 353: 267-274.
Wang Y, Li H, Zhang Y, Gu Z, Li Z, Wang Q. 2006. Analysis on Association of a SNP in the Chicken OBR Gene with Growth and Body Composition Traits. Asian-Aust J. Anim. Sci. 19(12): 1706–1710.
Zhang W, Aggrey SE. 2003. Genetic variation in feed utilization efficiency of meat-type chickens. World’s Poult. Sci. J. 59: 328–339.
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature. 372: 425–431.
Published
2021-02-27
How to Cite
MAHARDHIKA, I Wayan Swarautama; DARYONO, Budi Setiadi. RECENT DEVELOPMENT IN INVESTIGATION OF CHICKEN LEPTIN GENE: A REVIEW. Buletin Veteriner Udayana, [S.l.], p. 81-92, feb. 2021. ISSN 2477-2712. Available at: <https://ojs.unud.ac.id/index.php/buletinvet/article/view/50370>. Date accessed: 23 sep. 2021. doi: https://doi.org/10.24843/bulvet.2021.v13.i01.p13.
Section
Articles