BIO-MOLECULAR STUDY OF JEMBRANA VIRUS: AS BASIC DEVELOPMENT OF TISSUE CULTURE VACCINE
Abstract
Phatogenesis and bio-molecular of jembrana disease virus (JDV) only attack B-cell as a target, causing no produced antibody until 2-3 months post infection. Significantly increasing the number of CD8+ T-cells and significantly decreasing of CD4+ T-cells during acute phase affecting in decreased of CD8+:CD4+ ratio, that resulting in increasing sensitifity of animal to secunder infection. Nine bali cattle used in this study grouped based on infection status related to sample collected. Seven bali cattle infected by JDV isolate Tabanan/87 and two other cattle infected by BIV isolate R29, as a negative control (Non-JDV infected cattle). Samples tested of cellular identity and targeted cell, cellular immunity and cytokine expressions. Samples tested by flow cytometry and analyzed by variance. The result showed that the change of T-cell sub-population related to recovery of JVD infection strengthen the role of cellular immunity in a process of healing Jembrana disease. Evidences of enhancement of cytokine gene expressions produced by CDB T-cell mainly by IFN-g and IL-2, indicated the importance of those genes in an infection process and recovery.
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References
Abbas AK, Murphy KM, Sher A. 1996. Functional diversity of helper T lymphocytes. Nature, 383:787-793.
Bissel SJ, Wang G, Bonneh-Barkay D, Starkey A, Trichel AM, Murphey-Corb M, Wiley CA. 2008. Systemic and brain macrophage infections in relation to the development of simian immunodeficiency virus encephalitis. J Virol, 82: 5031-5042.
Carpenter S, Vaughn EM, Yang J, Baccam P, Roth JA, Wannemuehler Y. 2000. Antigenic and genetic stability of bovine immunodeficiency virus during long-term persistence in cattle experimentally infected with the BIV(R29) isolate. J Gen Virol, 81: 1463-1472.
Chadwick BJ, Coelen RJ, Sammels LM, Kertayadnya G, Wilcox GE, (1995a). Genomic sequence analysis identifies Jembrana disease virus as a new bovine lentivirus. J Gen Virol, 76: 189-192.
Chadwick BJ, Coelen RJ, Wilcox GE, Sammels LM, Kertayadnya G. 1995b. Nucleotide sequence analysis of Jembrana disease virus: a bovine lentivirus associated with an acute disease syndrome. J Gen Virol, 76: 1637-1650.
Clapham PR, McKnight A. 2002. Cell surface receptors, virus entry and tropism of primate lentiviruses. J Gen Virol, 83: 1809-1829.
Conge AM, Tarte K, Reynes J, Segondy M, Gerfaux J, Zembala M,Vendrell JP. 1998. Impairment of B-lymphocyte differentiation induced by dual triggering of the B-cell antigen receptor and CD40 in advanced HIV-1-disease. Aids, 12: 1437-1449.
Copeland KF, McKay PJ, Rosenthal KL. 1995. Suppression of activation of the human immunodeficiency virus long terminal repeat by CD8+ T cells is not lentivirus specific. AIDS Res Hum Retroviruses, 11: 1321-1326
Desport M, Stewart ME, Mikosza AS, Sherida CA, Peterson SE, Chavand O, Hartaningsih N, Wilcox GE. 2007. Sequence analysis of Jembrana disease virus strains reveals a genetically stable lentivirus. Virus Res, 126: 233-244.
Dharma DM, Budiantono A, Campbell RS, Ladds PW. 1991. Studies on experimental Jembrana disease in Bali cattle. III. Pathology. J Comp Pathol, 105: 397-414.
Dharma DM, Ladds PW, Wilcox GE, Campbell RS. 1994. Immunopathology of experimental Jembrana disease in Bali cattle. Vet Immunol Immunopathol, 44: 31-44.
Espinoza JC, Kuznar J. 2009. Visualization of the infectious pancreatic necrosis virus replication cycle by labeling viral intermediates with a TUNEL assay. Vet Microbiol.
M. (1989). Identification and biologic characterization of an acutely lethal variant of simian immunodeficiency virus from sooty mangabeys (SIV/SMM). AIDS Res Hum Retroviruses, 5: 397-409.
Gonzalez-Scarano F, Martin-Garcia J. 2005. The neuropathogenesis of AIDS. Nat Rev Immunol 5: 69-81.
Hartaningsih N, Wilcox GE, Kertayadnya G, Astawa M. 1994. Antibody response to Jembrana disease virus in Bali cattle. Vet Microbiol, 39: 15-23.
Heaton PR, Johnstone P, Brownlie J. 1998. Investigation of the cellular tropism of bovine immunodeficiency-like virus. Res Vet Sci, 65, 33-40.
Kabeya H, Ohashi K, Oyunbileg N, Nagaoka Y, Aida Y, Sugimoto C, Yokomizo Y, Onuma M. 1999. Up-regulation of tumor necrosis factor alpha mRNA is associated with bovine-leukemia virus (BLV) elimination in the early phase of infection. Vet Immunol Immunopathol, 68: 255-265.
Konnai S, Usui T, Ohashi K, Onuma M. 2003. The rapid quantitative analysis of bovine cytokine genes by real-time RT-PCR. Vet Microbiol, 94: 283-294.
Leutenegger CM, Alluwaimi AM, Smith WL, Perani L, Cullor JS. (2000). Quantitation of bovine cytokine mRNA in milk cells of healthy cattle by real-time TaqMan polymerase chain reaction. Vet Immunol Immunopathol, 77: 275-287.
Martojo H. 2003. A simple selection program for smallholder Bali cattle farmers. In Strategies to improve Bali cattle in Eastern Indonesia, pp. 43-53. Edited by K. Entwistle and D. R. Lindsay: Australian Centre for International Agricultural Research.
Mason DY, Micklem K, Jones M. 2000. Double immunofluorescence labelling of routinely processed paraffin sections. J Pathol, 191: 452-461.
Migueles SA, Laborico AC, Shupert WL, Sabbaghian MS, Rabin R, Hallahan CW, Van Baarle D, Kostense S, Miedema F. 2002. HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat Immunol, 3: 1061-1068.
Murakami K, Sentsui H, Shibahara T, Yokoyama T. 1999. Reduction of CD4+ and CD8+ T lymphocytes during febrile periods in horses experimentally infected with equine infectious anemia virus. Vet Immunol Immunopathol, 67: 131-140.
Muro-Cacho CA, Pantaleo G, Fauci AS. 1995. Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden. J Immunol, 154: 5555-5566.
Oaks JL, McGuire TC, Ulibarri C, Crawford TB. 1998. Equine infectious anemia virus is found in tissue macrophages during subclinical infection. J Virol, 72: 7263-7269.
O'Neil SP, Mossman SP, Maul DH, Hoover EA. 1999. In vivo cell and tissue tropism of SIVsmmPBj14-bcl.3. AIDS Res Hum Retroviruses, 15: 203-215
Pantaleo G, Soudeyns H, Demarest JF, Vaccarezza M, Graziosi C, Paolucci S, Daucher M, Cohen OJ, Denis F. (1997a). Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection. Proc Natl Acad Sci U S A 94, 9848-9853.
Pantaleo G, Demarest JF, Schacker T, Vaccarezza M, Cohen OJ, Daucher M, Graziosi C, Schnittman SS, Quinn TC. 1997b. The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. Proc Natl Acad Sci U S A 94: 254-258.
Shirai A, Cosentino M, Leitman-Klinman SF, Klinman DM. 1992. Human immunodeficiency virus infection induces both polyclonal and virus-specific B cell activation. J Clin Invest, 89: 561-566.
Soeharsono S, Hartaningsih N, Soetrisno M, Kertayadnya G, Wilcox GE. 1990. Studies of experimental Jembrana disease in Bali cattle. I. Transmission and persistence of the infectious agent in ruminants and pigs, and resistance of recovered cattle to re-infection. J Comp Pathol, 103: 49-59.
Soesanto M, Soeharsono S, Budiantono A, Sulistyana K, Tenaya M, Wilcox GE. 1990. Studies on experimental Jembrana disease in Bali cattle. II. Clinical signs and haematological changes. J Comp Pathol, 103: 61-71.
Stephens EB, Mukherjee S, Liu ZQ, Sheffer D, Lamb-Wharton R, Leung K, Zhuge W, Joag SV, Li Z.1998. Simian-human immunodeficiency virus (SHIV) containing the nef/long terminal repeat region of the highly virulent SIVsmmPBj14 causes PBj-like activation of cultured resting peripheral blood mononuclear cells, but the chimera showed No increase in virulence. J Virol, 72, 5207-5214.
Stewart M, Desport M, Hartaningsih N, Wilcox G. 2005. TaqMan real-time reverse transcription-PCR and JDVp26 antigen capture enzyme-linked immunosorbent assay to quantify Jembrana disease virus load during the acute phase of in vivo infection. J Clin Microbiol, 43: 5574-5580.
Talib C, Entwistle K, Sirega A, Budiarti-Turner S, Lindsay D. 2002. Survey of population and production dynamics of Bali cattle and existing breeding programs in Indonesia. In In proceeding of an Aciar Workshop on "Strategies to Improve Bali Cattle in estern Indonesia". Denpasar-Bali-Indonesia.
Wareing S, Hartaningsih N, Wilcox GE, Penhale WJ. 1999. Evidence for immunosuppression associated with Jembrana disease virus infection of cattle. Vet Microbiol, 68: 179-185.
Wiryosuhanto S. 1996. Bali cattle -their economic important in Indonesia. In Workshop on Jembrana Disease and the Bovine Lentiviruses pp. 34-41. Edited by G. E. Wilcox S, Soeharsono, Dharma DMN, Copland JW. Australian Centre for International Agricultural Research.
Zagury D, Lachgar A, Chams V, Fall LS, Bernard J, Zagury JF, Bizzini B, Gringeri A, Santagostino E. .1998.. C-C chemokines, pivotal in protection against HIV type 1 infection. Proc Natl Acad Sci U S A 95: 3857-3861.
Zhang J, Madden TL. 1997. PowerBLAST: a new network BLAST application for interactive or automated sequence analysis and annotation. Genome Res, 7: 649-656.
Bissel SJ, Wang G, Bonneh-Barkay D, Starkey A, Trichel AM, Murphey-Corb M, Wiley CA. 2008. Systemic and brain macrophage infections in relation to the development of simian immunodeficiency virus encephalitis. J Virol, 82: 5031-5042.
Carpenter S, Vaughn EM, Yang J, Baccam P, Roth JA, Wannemuehler Y. 2000. Antigenic and genetic stability of bovine immunodeficiency virus during long-term persistence in cattle experimentally infected with the BIV(R29) isolate. J Gen Virol, 81: 1463-1472.
Chadwick BJ, Coelen RJ, Sammels LM, Kertayadnya G, Wilcox GE, (1995a). Genomic sequence analysis identifies Jembrana disease virus as a new bovine lentivirus. J Gen Virol, 76: 189-192.
Chadwick BJ, Coelen RJ, Wilcox GE, Sammels LM, Kertayadnya G. 1995b. Nucleotide sequence analysis of Jembrana disease virus: a bovine lentivirus associated with an acute disease syndrome. J Gen Virol, 76: 1637-1650.
Clapham PR, McKnight A. 2002. Cell surface receptors, virus entry and tropism of primate lentiviruses. J Gen Virol, 83: 1809-1829.
Conge AM, Tarte K, Reynes J, Segondy M, Gerfaux J, Zembala M,Vendrell JP. 1998. Impairment of B-lymphocyte differentiation induced by dual triggering of the B-cell antigen receptor and CD40 in advanced HIV-1-disease. Aids, 12: 1437-1449.
Copeland KF, McKay PJ, Rosenthal KL. 1995. Suppression of activation of the human immunodeficiency virus long terminal repeat by CD8+ T cells is not lentivirus specific. AIDS Res Hum Retroviruses, 11: 1321-1326
Desport M, Stewart ME, Mikosza AS, Sherida CA, Peterson SE, Chavand O, Hartaningsih N, Wilcox GE. 2007. Sequence analysis of Jembrana disease virus strains reveals a genetically stable lentivirus. Virus Res, 126: 233-244.
Dharma DM, Budiantono A, Campbell RS, Ladds PW. 1991. Studies on experimental Jembrana disease in Bali cattle. III. Pathology. J Comp Pathol, 105: 397-414.
Dharma DM, Ladds PW, Wilcox GE, Campbell RS. 1994. Immunopathology of experimental Jembrana disease in Bali cattle. Vet Immunol Immunopathol, 44: 31-44.
Espinoza JC, Kuznar J. 2009. Visualization of the infectious pancreatic necrosis virus replication cycle by labeling viral intermediates with a TUNEL assay. Vet Microbiol.
M. (1989). Identification and biologic characterization of an acutely lethal variant of simian immunodeficiency virus from sooty mangabeys (SIV/SMM). AIDS Res Hum Retroviruses, 5: 397-409.
Gonzalez-Scarano F, Martin-Garcia J. 2005. The neuropathogenesis of AIDS. Nat Rev Immunol 5: 69-81.
Hartaningsih N, Wilcox GE, Kertayadnya G, Astawa M. 1994. Antibody response to Jembrana disease virus in Bali cattle. Vet Microbiol, 39: 15-23.
Heaton PR, Johnstone P, Brownlie J. 1998. Investigation of the cellular tropism of bovine immunodeficiency-like virus. Res Vet Sci, 65, 33-40.
Kabeya H, Ohashi K, Oyunbileg N, Nagaoka Y, Aida Y, Sugimoto C, Yokomizo Y, Onuma M. 1999. Up-regulation of tumor necrosis factor alpha mRNA is associated with bovine-leukemia virus (BLV) elimination in the early phase of infection. Vet Immunol Immunopathol, 68: 255-265.
Konnai S, Usui T, Ohashi K, Onuma M. 2003. The rapid quantitative analysis of bovine cytokine genes by real-time RT-PCR. Vet Microbiol, 94: 283-294.
Leutenegger CM, Alluwaimi AM, Smith WL, Perani L, Cullor JS. (2000). Quantitation of bovine cytokine mRNA in milk cells of healthy cattle by real-time TaqMan polymerase chain reaction. Vet Immunol Immunopathol, 77: 275-287.
Martojo H. 2003. A simple selection program for smallholder Bali cattle farmers. In Strategies to improve Bali cattle in Eastern Indonesia, pp. 43-53. Edited by K. Entwistle and D. R. Lindsay: Australian Centre for International Agricultural Research.
Mason DY, Micklem K, Jones M. 2000. Double immunofluorescence labelling of routinely processed paraffin sections. J Pathol, 191: 452-461.
Migueles SA, Laborico AC, Shupert WL, Sabbaghian MS, Rabin R, Hallahan CW, Van Baarle D, Kostense S, Miedema F. 2002. HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat Immunol, 3: 1061-1068.
Murakami K, Sentsui H, Shibahara T, Yokoyama T. 1999. Reduction of CD4+ and CD8+ T lymphocytes during febrile periods in horses experimentally infected with equine infectious anemia virus. Vet Immunol Immunopathol, 67: 131-140.
Muro-Cacho CA, Pantaleo G, Fauci AS. 1995. Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden. J Immunol, 154: 5555-5566.
Oaks JL, McGuire TC, Ulibarri C, Crawford TB. 1998. Equine infectious anemia virus is found in tissue macrophages during subclinical infection. J Virol, 72: 7263-7269.
O'Neil SP, Mossman SP, Maul DH, Hoover EA. 1999. In vivo cell and tissue tropism of SIVsmmPBj14-bcl.3. AIDS Res Hum Retroviruses, 15: 203-215
Pantaleo G, Soudeyns H, Demarest JF, Vaccarezza M, Graziosi C, Paolucci S, Daucher M, Cohen OJ, Denis F. (1997a). Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection. Proc Natl Acad Sci U S A 94, 9848-9853.
Pantaleo G, Demarest JF, Schacker T, Vaccarezza M, Cohen OJ, Daucher M, Graziosi C, Schnittman SS, Quinn TC. 1997b. The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. Proc Natl Acad Sci U S A 94: 254-258.
Shirai A, Cosentino M, Leitman-Klinman SF, Klinman DM. 1992. Human immunodeficiency virus infection induces both polyclonal and virus-specific B cell activation. J Clin Invest, 89: 561-566.
Soeharsono S, Hartaningsih N, Soetrisno M, Kertayadnya G, Wilcox GE. 1990. Studies of experimental Jembrana disease in Bali cattle. I. Transmission and persistence of the infectious agent in ruminants and pigs, and resistance of recovered cattle to re-infection. J Comp Pathol, 103: 49-59.
Soesanto M, Soeharsono S, Budiantono A, Sulistyana K, Tenaya M, Wilcox GE. 1990. Studies on experimental Jembrana disease in Bali cattle. II. Clinical signs and haematological changes. J Comp Pathol, 103: 61-71.
Stephens EB, Mukherjee S, Liu ZQ, Sheffer D, Lamb-Wharton R, Leung K, Zhuge W, Joag SV, Li Z.1998. Simian-human immunodeficiency virus (SHIV) containing the nef/long terminal repeat region of the highly virulent SIVsmmPBj14 causes PBj-like activation of cultured resting peripheral blood mononuclear cells, but the chimera showed No increase in virulence. J Virol, 72, 5207-5214.
Stewart M, Desport M, Hartaningsih N, Wilcox G. 2005. TaqMan real-time reverse transcription-PCR and JDVp26 antigen capture enzyme-linked immunosorbent assay to quantify Jembrana disease virus load during the acute phase of in vivo infection. J Clin Microbiol, 43: 5574-5580.
Talib C, Entwistle K, Sirega A, Budiarti-Turner S, Lindsay D. 2002. Survey of population and production dynamics of Bali cattle and existing breeding programs in Indonesia. In In proceeding of an Aciar Workshop on "Strategies to Improve Bali Cattle in estern Indonesia". Denpasar-Bali-Indonesia.
Wareing S, Hartaningsih N, Wilcox GE, Penhale WJ. 1999. Evidence for immunosuppression associated with Jembrana disease virus infection of cattle. Vet Microbiol, 68: 179-185.
Wiryosuhanto S. 1996. Bali cattle -their economic important in Indonesia. In Workshop on Jembrana Disease and the Bovine Lentiviruses pp. 34-41. Edited by G. E. Wilcox S, Soeharsono, Dharma DMN, Copland JW. Australian Centre for International Agricultural Research.
Zagury D, Lachgar A, Chams V, Fall LS, Bernard J, Zagury JF, Bizzini B, Gringeri A, Santagostino E. .1998.. C-C chemokines, pivotal in protection against HIV type 1 infection. Proc Natl Acad Sci U S A 95: 3857-3861.
Zhang J, Madden TL. 1997. PowerBLAST: a new network BLAST application for interactive or automated sequence analysis and annotation. Genome Res, 7: 649-656.
Published
2016-08-13
How to Cite
TANAYA, I Wayan Masa.
BIO-MOLECULAR STUDY OF JEMBRANA VIRUS: AS BASIC DEVELOPMENT OF TISSUE CULTURE VACCINE.
Buletin Veteriner Udayana, [S.l.], aug. 2016.
ISSN 2477-2712.
Available at: <https://ojs.unud.ac.id/index.php/buletinvet/article/view/23318>. Date accessed: 12 nov. 2024.
Section
Articles
Keywords
virus penyakit jembrana; sapi bali; sitokin; in vitro; Jembrana disease virus; bali cattle; cytokine; in vitro
