Cinnamon Extract Effect on Osteoblast Activity in Diabetic Wistar Rats

  • Fahrin Ramadan Andiwijaya Faculty of Medicine, Airlangga University
  • Fundhy Sinar Ikrar Prihatanto Anatomy and Histology Department, Faculty of Medicine, Airlangga University
  • Hermawan Susanto Endocrine and Metabolism Division, Internal Department RSUD dr. Soetomo, Airlangga University

Abstract

Background: Diabetes is clinically known to cause prolongation to bone fracture healing. This research aims to find the effect of cinnamon in the process of bone remodeling, and changes in the activity of osteoblast cells in diabetic bone after giving cinnamon as a supplement in diabetic rats. Method: The design employed was experimental with randomized post-test group design research. A total of 24 Wistar Rats was randomly divided into four groups, which consist of normal without treatment, normal with treatment, diabetic without treatment and diabetic with treatment. Treatment of 300 mg/kg cinnamon extract was given per orally. Upon euthanizing the samples, femur samples were taken and processed to histopathological slides. All slides were analyzed under light microscopes to find the osteoblast cells. The Kruskal-Wallis method was used to test the results; due to the population of sample was not normally distributed. Results: The osteoblast cells found were scored in mean ranks. The normal group mean rank 12.25, normal with treatment group 12.17, diabetic without treatment group 8.58, and diabetic with treatment group 17.00. Asymptotic significance was 0.195. Conclusion: This research concludes that there is no significant increase in osteoblast activity in diabetic Wistar rats after the administration of 300 mg/kg cinnamon extract.

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Author Biographies

Fahrin Ramadan Andiwijaya, Faculty of Medicine, Airlangga University
Faculty of Medicine, Airlangga University
Fundhy Sinar Ikrar Prihatanto, Anatomy and Histology Department, Faculty of Medicine, Airlangga University
Anatomy and Histology Department, Faculty of Medicine, Airlangga University
Hermawan Susanto, Endocrine and Metabolism Division, Internal Department RSUD dr. Soetomo, Airlangga University
Endocrine and Metabolism Division, Internal Department RSUD dr. Soetomo, Airlangga University
Published
2016-05-04
How to Cite
ANDIWIJAYA, Fahrin Ramadan; PRIHATANTO, Fundhy Sinar Ikrar; SUSANTO, Hermawan. Cinnamon Extract Effect on Osteoblast Activity in Diabetic Wistar Rats. BALI MEDICAL JOURNAL, [S.l.], v. 5, n. 2, may 2016. ISSN 2302-2914. Available at: <https://ojs.unud.ac.id/index.php/bmj/article/view/21798>. Date accessed: 21 nov. 2024.
Section
Articles

Keywords

Diabetes, Wistar Rats, Cinnamon, Histopathological, Osteoblast Cells.