Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Novel Markers for Diagnosis of Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis

  • Mohammad Amin Bahrami Associate Professor, Healthcare Management Department, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Abdollah Ansari Resident of Otolaryngology, Head and Neck Surgery, Otorhinolaryngology Research Center, Department of Otolaryngology, Head and neck surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Kefayat Chaman Ara Obstetrician and Gynecologist, Mehr Hospital, Borazjan, Iran
  • Elham Bahrami Obstetrician and Gynecologist, Ayatollah Khatami Hospital, Yazd, Iran
  • Sima Bahrami Medicine Student, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Mohammad Nabi Bahrami Orthopaedic Resident, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Omid Barati Assistant Professor, Healthcare Management Department, Shiraz University of Medical Sciences, Shiraz, Iran
  • Mahmood Moosazadeh Assistant Professor, Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran
  • Rauf O?guzhan Kum Ankara Numune Education and Research Hospital ENT Clinic, Ankara, Turkey

Abstract

Background: Sudden sensorineural hearing loss (SSNHL) is a common otologic disease characterized by a loss of hearing greater than 30 dB in three consecutive frequencies which occurs in less than 72 hours. Objective: To investigate the role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) on sudden sensorineural hearing loss (SSNHL). Search strategy: A PubMed, Science Direct, Scopus, OVID, EMBASE and Google Scholar search (date last searched April 2016) without any time, language and location restriction was done. Inclusion criteria: All case-control studies, which have been investigated the relationship of NLR and PLR with the occurrence of SSNHL were included in our meta-analysis. Results: A total of 5 case-control studies were included in the study. All 5 studies have been reported NLR of patients and control groups (611 patients and 804 controls). Our analysis showed that the mean NLR of patients is 1.12 (0.82-1.43) unit higher than that of controls with 95% CI which is statistically significant. Also, 3 studies have been reported PLR of patients and control groups (512 patients and 705 controls). Our analysis showed that the mean PLR of patients is 0.57 (0.08-1.05) unit higher than that of controls with 95% CI which is statistically significant too. Conclusions: This metaanalysis confirmed the relationship of NLR and PLR with SSNHL. Therefore, these parameters can be considered as new markers in diagnosis of SSNHL.

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Author Biographies

Mohammad Amin Bahrami, Associate Professor, Healthcare Management Department, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Associate Professor, Healthcare Management Department, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abdollah Ansari, Resident of Otolaryngology, Head and Neck Surgery, Otorhinolaryngology Research Center, Department of Otolaryngology, Head and neck surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Resident of Otolaryngology, Head and Neck Surgery, Otorhinolaryngology Research Center, Department of Otolaryngology, Head and neck surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Kefayat Chaman Ara, Obstetrician and Gynecologist, Mehr Hospital, Borazjan, Iran
Obstetrician and Gynecologist, Mehr Hospital, Borazjan, Iran
Elham Bahrami, Obstetrician and Gynecologist, Ayatollah Khatami Hospital, Yazd, Iran
Obstetrician and Gynecologist, Ayatollah Khatami Hospital, Yazd, Iran
Sima Bahrami, Medicine Student, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Medicine Student, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mohammad Nabi Bahrami, Orthopaedic Resident, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Orthopaedic Resident, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Omid Barati, Assistant Professor, Healthcare Management Department, Shiraz University of Medical Sciences, Shiraz, Iran
Assistant Professor, Healthcare Management Department, Shiraz University of Medical Sciences, Shiraz, Iran
Mahmood Moosazadeh, Assistant Professor, Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran
Assistant Professor, Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran
Rauf O?guzhan Kum, Ankara Numune Education and Research Hospital ENT Clinic, Ankara, Turkey
Ankara Numune Education and Research Hospital ENT Clinic, Ankara, Turkey
Published
2016-04-30
How to Cite
BAHRAMI, Mohammad Amin et al. Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Novel Markers for Diagnosis of Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis. BALI MEDICAL JOURNAL, [S.l.], v. 5, n. 2, apr. 2016. ISSN 2302-2914. Available at: <https://ojs.unud.ac.id/index.php/bmj/article/view/21796>. Date accessed: 13 nov. 2024.
Section
Articles

Keywords

Sudden sensorineural hearing loss, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio

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