Dynamics of Human Mesenchymal Stem Cells, M1 Microglia/Macrophage, and Fractalkine in Ischemic Stroke Patients
Abstract
Background: About 85% of strokes are ischemic strokes, caused by occlusion of cerebral artery that induced brain inflammation. A deep understanding of ischemic stroke mechanism will lead to better neurorestorative treatment. Objective: This study investigates the dynamics of human mesenchymal stem cells, fractalkine, and M1 microglia/macrophage in ischemic stroke patients. Results: We found the same fractalkine levels and M1 microglia/macrophage cells on patients with stroke onset 0 to 14 days, then decrease until 30 days of stroke onset. MSCs was increase 7 days after stroke onset, peaked by 14 days, then decreased until 30 days after stroke ischemic onset. Conclusions: This study found an interaction between microglia/macrophage, fractalkine, and MSCs on ischemic stroke patients, so therapeutic strategy could be developed.Downloads
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Published
2016-04-30
How to Cite
HERMINAWATI, Lucia et al.
Dynamics of Human Mesenchymal Stem Cells, M1 Microglia/Macrophage, and Fractalkine in Ischemic Stroke Patients.
BALI MEDICAL JOURNAL, [S.l.], v. 5, n. 1, apr. 2016.
ISSN 2302-2914.
Available at: <https://ojs.unud.ac.id/index.php/bmj/article/view/21792>. Date accessed: 21 nov. 2024.
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Section
Articles
Keywords
ischemic stroke, microglia, fractalkine, mesenchymal stem cells