Dynamics of Human Mesenchymal Stem Cells, M1 Microglia/Macrophage, and Fractalkine in Ischemic Stroke Patients

  • Lucia Herminawati Postgraduate Program in Clinical Biochemistry, Hasanuddin University, Indonesia
  • Andi Wijaya Postgraduate Program in Clinical Biochemistry, Hasanuddin University, Indonesia Prodia Clinical Laboratory, Indonesia Prodia Diagnostic Line, Indonesia
  • Mansyur Arief Postgraduate Program in Clinical Biochemistry, Hasanuddin University, Indonesia
  • Suryani As’ad Postgraduate Program in Clinical Biochemistry, Hasanuddin University, Indonesia

Abstract

Background: About 85% of strokes are ischemic strokes, caused by occlusion of cerebral artery that induced brain inflammation. A deep understanding of ischemic stroke mechanism will lead to better neurorestorative treatment. Objective: This study investigates the dynamics of human mesenchymal stem cells, fractalkine, and M1 microglia/macrophage in ischemic stroke patients. Results: We found the same fractalkine levels and M1 microglia/macrophage cells on patients with stroke onset 0 to 14 days, then decrease until 30 days of stroke onset. MSCs was increase 7 days after stroke onset, peaked by 14 days, then decreased until 30 days after stroke ischemic onset. Conclusions: This study found an interaction between microglia/macrophage, fractalkine, and MSCs on ischemic stroke patients, so therapeutic strategy could be developed.

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Author Biographies

Lucia Herminawati, Postgraduate Program in Clinical Biochemistry, Hasanuddin University, Indonesia
Prodia Diagnostic Line, Indonesia
Andi Wijaya, Postgraduate Program in Clinical Biochemistry, Hasanuddin University, Indonesia Prodia Clinical Laboratory, Indonesia Prodia Diagnostic Line, Indonesia
Prodia Diagnostic Line, Indonesia
Mansyur Arief, Postgraduate Program in Clinical Biochemistry, Hasanuddin University, Indonesia
Postgraduate Program in Clinical Biochemistry, Hasanuddin University, Indonesia
Suryani As’ad, Postgraduate Program in Clinical Biochemistry, Hasanuddin University, Indonesia
Postgraduate Program in Clinical Biochemistry, Hasanuddin University, Indonesia
Published
2016-04-30
How to Cite
HERMINAWATI, Lucia et al. Dynamics of Human Mesenchymal Stem Cells, M1 Microglia/Macrophage, and Fractalkine in Ischemic Stroke Patients. BALI MEDICAL JOURNAL, [S.l.], v. 5, n. 1, apr. 2016. ISSN 2302-2914. Available at: <https://ojs.unud.ac.id/index.php/bmj/article/view/21792>. Date accessed: 13 nov. 2024.
Section
Articles

Keywords

ischemic stroke, microglia, fractalkine, mesenchymal stem cells