Pemberian musik klasik, musik rock, dan murottal Al-Qur’an pada induk bunting terhadap perkembangan cerebrum fetus mencit (Mus musculus)
Abstract
Perkembangan otak pada fetus mencit (Mus musculus) saat di dalam uterus induk dipengaruhi berbagai faktor, salah satunya adalah suara (musik). Berbagai genre musik dapat memberikan efek yang berbeda terhadap perkembangan otak pada fetus mencit. Penelitian ini memiliki tujuan mengetahui efek pemberian musik klasik, musik rock, dan murottal Al-Qur’an pada induk bunting terhadap perkembangan cerebrum fetus mencit. Penelitian menggunakan Rancangan Acak Lengkap (RAL) pada empat perlakuan terdiri dari kontrol (K0), musik klasik (K1), musik rock (K2), dan murottal Al-Qur’an (K3), dengan enam ulangan. Parameter yang diamati adalah bobot cerebrum, jumlah sel piramidal, dan neuroglia. Pengamatan dilakukan dengan menggunakan mikroskop cahaya yang dilengkapi dengan optilab dan setiap preparat diamati lima lapang pandang. Analisis data yang terdistribusi normal dan homogen dengan uji ANOVA dan dilanjut Uji Duncan. Data yang terdistribusi normal namun tidak homogen dan data yang terdistribusi tidak normal tetapi homogen dianalisis dengan uji Kruskal-Wallis dan dilanjut uji Mann-Whitney. Hasil penelitian menunjukkan bahwa stimulasi musik yang optimum meningkatkan jumlah sel piramidal dan neuroglia terhadap perkembangan cerebrum fetus mencit adalah murottal Al-Qur'an (K3) dan musik klasik (K1).
Downloads
Download data is not yet available.
References
Bast A, Fruengel R, de Kock CPJ, Oberlaender M. 2024. Network-neuron interactions underlying sensory responses of layer 5 pyramidal tract neurons in barrel cortex. PLoS Computational Biology 20(4): 1-23.
Chatterjee D, Hegde S, Thaut M. 2021. Neural plasticity: The substratum of music-based interventions in neurorehabilitation. NeuroRehabilitation 48(2): 155-166.
Chaudhury D, Walsh JJ, Friedman AK, Juarez B, Ku SM, Koo JW, Ferguson D, Tsai HC, Pomeranz L, Christoffel DJ, Nectow AR, Ekstrand M, Domingos A, Robinson MSM, Mouzon E, Lobo MK, Neve RL, Friedman JM, Russo SJ, Deisseroth K, Nestler EJ, Han MH. 2013. Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature 493(7433): 532-536.
Fitzgerald E, Hor K, Drake AJ. 2020. Maternal Influences on Fetal Brain Development: The Role of Nutrition, Infection and Stress, and The Potential For Intergenerational Consequences. Early Human Development 15(105190): 1-6
Hanswijk SI, Spoelder M, Shan L, Verheij MMM, Muilwijk OG, Li W, Liu C, Kolk SM, Homberg JR. 2020. Gestational factors throughout fetal neurodevelopment: the serotonin link. International Journal of Molecular Sciences 21(16): 5850.
Hasan AZ, Alilah NH, Rahman ZBA, Fa’atin S, Kamaluddin MR. 2023. Neuroscience’s principles and al-qur’an recital approaches used on covid-19 patients during the covid-19 pandemic in malaysia. Journal of Pharmaceitocal Negative Results 14(2): 2490-2497.
Hood RD. 2012. Developmental and Reproductive Toxicology: A Practical Approach. CRC Press: Boca Raton.
Ismail S, Sharifudin MA, Reza MF, Juahir H. 2021. Unveiling the neuronal mechanism during listening to quranic recitation. International Journal of Allied Health Sciences 5(1): 2134.
Joewono HT. 2020. The evidence for the influence of musical compositions during pregnancy to the structure and functions of the offsprings’ brain. Majalah Obstetri & Ginekologi 28(1): 44–51.
Khasanah RN, Joewono HT, Widjiati. 2021. Musik mozart memiliki jumlah sel glia terbanyak pada cerebrum dan cerebellum rattus norvegicus baru lahir dibandingkan dengan gamelan jawa, sunda dan bali selama kehamilan. Jurnal Ilmiah Ilmu Kesehatan 9(2): 359-364.
Kim H, Lee MH, Chang HK, Lee TH, Lee HH, Shin MC, Shin MS, Won R, Shin HS, Kim CJ. 2006. Influence of prenatal noise and music on the spatial memory and neurogenesis in the hippocampus of developing rats. Brain Dev. 28(2): 109-114.
Knight WEJ, Rickard NS. 2001. Relaxing music prevents stress-induced increases in subjective anxiety, systolic blood pressure, and heart rate in healthy males and females. Journal of Music Therapy 38(4): 254-272.
Kristyanto H, Sonia S, Rapih P, Natsir A, Suraya F, Ibrahim N. 2010. Pengaruh musik klasik dan musik rock terhadap nafsu makan dan berat badan tikus. Maj Kedokt Indon. 60(5): 219-226.
Kurniasari S, Yanti AH, Setyawati TR. 2017. Kadar malondialdehyde induk dan struktur morfologis fetus mencit (Mus musculus) yang diperdengarkan murottal dan musik rock pada periode gestasi. Protobiont. 6(3): 89-97.
Kusumarini S, Yustinasari LR, Hestianah EP, Kuncorojati S, Juniastuti T. 2017. Mozart kv 448 menurunkan densitas dan aktivitas neuroglia hipokampus mencit (Mus musculus) Selama Stres Prenatal No. 416-KE. Jurnal Sain Veteriner 35(1): 1-8.
Linderkamp O, Skoruppa DBL. 2020. Prenatal Structural Brain Development: Genetic and Environmental Determinants. Handbook of Prenatal and Perinatal Psychology. Springer Cham. 19-32
Nadila S, Joewono HT, Sulistyono A. 2022. Murottal sura al-fatiha during pregnancy increased the number of neuron cells in the cerebrum and cerebellum of the newborn Rattus norvegicus. International Journal of Health Sciences 6(3): 1383-1390.
Nofantri L, Berata IK, Adi AAAM. 2017. Studi histopatologi limpa dan otak ayam terinfeksi penyakit tetelo. Indonesia Medicus Veterinus 6(5): 419-429.
Norris DO. 2007. Vertebrate Endocrinolology Fourth Edition. Elsevier Academic Press: Burlington.
Octariyandra SM, Joewono HT dan Basuki M. 2019. Mozart compilation during pregnancy gave higher number of neurons of Rattus norvegicus offspring in cerebrum compared to jazz, blues, and rock compilation. Global Journal of Medical Research: E Gynecology and Obstetrics 19(4): 1-8.
Partanen E, Kujala T, Tervaniemi M, Huotilainen M. 2013. Prenatal music exposure induces long-term neural effects. PLoS ONE. 8(10): 1-6.
Peters SR. 2003. The art of embedding tissue for frozen section. Journal of Histotechnology 26(1): 11-19.
Psyrdellis M, Diaz Abrahan V, Cetratelli C, Justel N. 2017. Rock influences spatial memory in adult rats, while classical music do not. Psicológica 38(2): 177–193.
Putra AANK, Irwanto, I’tishom R, Setyoboedi B, Mustakim MRD. 2023. Mozart music stimulation effect on wistar rat’s neurogenesis. Bali Medical Journal 12(1): 921-925.
Rahayu PSE, Joewono HT, Widjiati, 2019. Mozart music increases the number of glial cells compared to indonesia pop and religious music. Jurnal Saintika Medika 15(2): 133-138.
Rahman F, Syah H, Cahyadi A, Sabda S. 2023. Quantum ikhlas: kajian, analisis, dan implementasinya dalam pendidikan islam. Jurnal Alwatzikhoebillah 9(1): 34-48.
Rees WD. 2019. Interactions Between Nutrients in The Maternal Diet and The Implications for The Long-Term Health of The Offspring. Proceedings of The Nutrition Society 78(1): 88-96.
Saftarina F, Wardani D. 2016. Pengaruh musik rock dalam meningkatkan nafsu makan. Majority 5(1): 28-32.
Salafas E, Lestari P, Listiyaningsih MD. 2020. The effectiveness of music therapy in reducing anxiety in third trimester of pregnancy. SIKLUS: Journal Research Midwifery Politeknik Tegal 9(1): 39-44.
Saleh, MCI, Agustina DM, Hakim L. 2018. Pengaruh murottal al-qur’an terhadap tingkat kecemasan pada pasien jantung. Jurnal Keperawatan Suaka Insan 3(2): 1-9.
Sanyal T, Palanisamy P, Nag TC, Roy TS, Wadhwa S. 2013. Effect of prenatal loud music and noise on total number of neurons and glia, neuronal nuclear area and volume of chick brainstem auditory nuclei, field l and hippocampus: a stereological investigation. International Journal of Developmental Neuroscience 31(4): 234-244.
Sharma V. 2023. The impact of classical music on neuroanatomy and brain functions. Brain Matters 6(2): 28-30.
Sugita N. 1918. Comparative studies on the growth of the cerebral cortex. The Journal of Comparative Neurology 29(2): 61-117.
Supradewi R. 2010. Otak, musik, dan proses belajar. Buletin Psikologi 18(2): 58-68.
Tizabi Y, Getachew B, Hauser SR, Tsytsarev V, Manhaes AC, Victor. 2024. Role of glial cells in neuronal function, mood disorders, and drug addiction. Brain Sciences 14(6): 558.
Toader C, Tataru CP, Florian I, Covache-Busuioc R, Bratu B, Glavan LA, Bordeianu A, Dumitrascu D. 2023. Cognitive crescendo: how music shapes the brain’s structure and function. Brain Sciences 13(10): 1390.
Wahyuni S, Badriah B, Cahyati Y. 2021. Effect murottal therapy on blood pressure of pregnant women with hypertension. Journal of Nursing Care 4(1): 277-284.
Wang J, Wang J, Wang Y, Chai Y, Li H, Miao D, Liu H, Li J, Bao J. 2023. Music with different tones affects the development of brain nerves in mice in early life through BDNF and its downstream pathways. International Journal of Molecular Sciences 24(9): 8119
Yani AP, Joewono HT, Widjiati. 2021. Effect murottal sound stimulation during pregnancy on the number of neuron cells of cerebrum and cerebellum of the newborn Rattus norvegicus. Indian Journal Of Forensic Medicine & Toxicology 15(4): 845-851.
Chatterjee D, Hegde S, Thaut M. 2021. Neural plasticity: The substratum of music-based interventions in neurorehabilitation. NeuroRehabilitation 48(2): 155-166.
Chaudhury D, Walsh JJ, Friedman AK, Juarez B, Ku SM, Koo JW, Ferguson D, Tsai HC, Pomeranz L, Christoffel DJ, Nectow AR, Ekstrand M, Domingos A, Robinson MSM, Mouzon E, Lobo MK, Neve RL, Friedman JM, Russo SJ, Deisseroth K, Nestler EJ, Han MH. 2013. Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature 493(7433): 532-536.
Fitzgerald E, Hor K, Drake AJ. 2020. Maternal Influences on Fetal Brain Development: The Role of Nutrition, Infection and Stress, and The Potential For Intergenerational Consequences. Early Human Development 15(105190): 1-6
Hanswijk SI, Spoelder M, Shan L, Verheij MMM, Muilwijk OG, Li W, Liu C, Kolk SM, Homberg JR. 2020. Gestational factors throughout fetal neurodevelopment: the serotonin link. International Journal of Molecular Sciences 21(16): 5850.
Hasan AZ, Alilah NH, Rahman ZBA, Fa’atin S, Kamaluddin MR. 2023. Neuroscience’s principles and al-qur’an recital approaches used on covid-19 patients during the covid-19 pandemic in malaysia. Journal of Pharmaceitocal Negative Results 14(2): 2490-2497.
Hood RD. 2012. Developmental and Reproductive Toxicology: A Practical Approach. CRC Press: Boca Raton.
Ismail S, Sharifudin MA, Reza MF, Juahir H. 2021. Unveiling the neuronal mechanism during listening to quranic recitation. International Journal of Allied Health Sciences 5(1): 2134.
Joewono HT. 2020. The evidence for the influence of musical compositions during pregnancy to the structure and functions of the offsprings’ brain. Majalah Obstetri & Ginekologi 28(1): 44–51.
Khasanah RN, Joewono HT, Widjiati. 2021. Musik mozart memiliki jumlah sel glia terbanyak pada cerebrum dan cerebellum rattus norvegicus baru lahir dibandingkan dengan gamelan jawa, sunda dan bali selama kehamilan. Jurnal Ilmiah Ilmu Kesehatan 9(2): 359-364.
Kim H, Lee MH, Chang HK, Lee TH, Lee HH, Shin MC, Shin MS, Won R, Shin HS, Kim CJ. 2006. Influence of prenatal noise and music on the spatial memory and neurogenesis in the hippocampus of developing rats. Brain Dev. 28(2): 109-114.
Knight WEJ, Rickard NS. 2001. Relaxing music prevents stress-induced increases in subjective anxiety, systolic blood pressure, and heart rate in healthy males and females. Journal of Music Therapy 38(4): 254-272.
Kristyanto H, Sonia S, Rapih P, Natsir A, Suraya F, Ibrahim N. 2010. Pengaruh musik klasik dan musik rock terhadap nafsu makan dan berat badan tikus. Maj Kedokt Indon. 60(5): 219-226.
Kurniasari S, Yanti AH, Setyawati TR. 2017. Kadar malondialdehyde induk dan struktur morfologis fetus mencit (Mus musculus) yang diperdengarkan murottal dan musik rock pada periode gestasi. Protobiont. 6(3): 89-97.
Kusumarini S, Yustinasari LR, Hestianah EP, Kuncorojati S, Juniastuti T. 2017. Mozart kv 448 menurunkan densitas dan aktivitas neuroglia hipokampus mencit (Mus musculus) Selama Stres Prenatal No. 416-KE. Jurnal Sain Veteriner 35(1): 1-8.
Linderkamp O, Skoruppa DBL. 2020. Prenatal Structural Brain Development: Genetic and Environmental Determinants. Handbook of Prenatal and Perinatal Psychology. Springer Cham. 19-32
Nadila S, Joewono HT, Sulistyono A. 2022. Murottal sura al-fatiha during pregnancy increased the number of neuron cells in the cerebrum and cerebellum of the newborn Rattus norvegicus. International Journal of Health Sciences 6(3): 1383-1390.
Nofantri L, Berata IK, Adi AAAM. 2017. Studi histopatologi limpa dan otak ayam terinfeksi penyakit tetelo. Indonesia Medicus Veterinus 6(5): 419-429.
Norris DO. 2007. Vertebrate Endocrinolology Fourth Edition. Elsevier Academic Press: Burlington.
Octariyandra SM, Joewono HT dan Basuki M. 2019. Mozart compilation during pregnancy gave higher number of neurons of Rattus norvegicus offspring in cerebrum compared to jazz, blues, and rock compilation. Global Journal of Medical Research: E Gynecology and Obstetrics 19(4): 1-8.
Partanen E, Kujala T, Tervaniemi M, Huotilainen M. 2013. Prenatal music exposure induces long-term neural effects. PLoS ONE. 8(10): 1-6.
Peters SR. 2003. The art of embedding tissue for frozen section. Journal of Histotechnology 26(1): 11-19.
Psyrdellis M, Diaz Abrahan V, Cetratelli C, Justel N. 2017. Rock influences spatial memory in adult rats, while classical music do not. Psicológica 38(2): 177–193.
Putra AANK, Irwanto, I’tishom R, Setyoboedi B, Mustakim MRD. 2023. Mozart music stimulation effect on wistar rat’s neurogenesis. Bali Medical Journal 12(1): 921-925.
Rahayu PSE, Joewono HT, Widjiati, 2019. Mozart music increases the number of glial cells compared to indonesia pop and religious music. Jurnal Saintika Medika 15(2): 133-138.
Rahman F, Syah H, Cahyadi A, Sabda S. 2023. Quantum ikhlas: kajian, analisis, dan implementasinya dalam pendidikan islam. Jurnal Alwatzikhoebillah 9(1): 34-48.
Rees WD. 2019. Interactions Between Nutrients in The Maternal Diet and The Implications for The Long-Term Health of The Offspring. Proceedings of The Nutrition Society 78(1): 88-96.
Saftarina F, Wardani D. 2016. Pengaruh musik rock dalam meningkatkan nafsu makan. Majority 5(1): 28-32.
Salafas E, Lestari P, Listiyaningsih MD. 2020. The effectiveness of music therapy in reducing anxiety in third trimester of pregnancy. SIKLUS: Journal Research Midwifery Politeknik Tegal 9(1): 39-44.
Saleh, MCI, Agustina DM, Hakim L. 2018. Pengaruh murottal al-qur’an terhadap tingkat kecemasan pada pasien jantung. Jurnal Keperawatan Suaka Insan 3(2): 1-9.
Sanyal T, Palanisamy P, Nag TC, Roy TS, Wadhwa S. 2013. Effect of prenatal loud music and noise on total number of neurons and glia, neuronal nuclear area and volume of chick brainstem auditory nuclei, field l and hippocampus: a stereological investigation. International Journal of Developmental Neuroscience 31(4): 234-244.
Sharma V. 2023. The impact of classical music on neuroanatomy and brain functions. Brain Matters 6(2): 28-30.
Sugita N. 1918. Comparative studies on the growth of the cerebral cortex. The Journal of Comparative Neurology 29(2): 61-117.
Supradewi R. 2010. Otak, musik, dan proses belajar. Buletin Psikologi 18(2): 58-68.
Tizabi Y, Getachew B, Hauser SR, Tsytsarev V, Manhaes AC, Victor. 2024. Role of glial cells in neuronal function, mood disorders, and drug addiction. Brain Sciences 14(6): 558.
Toader C, Tataru CP, Florian I, Covache-Busuioc R, Bratu B, Glavan LA, Bordeianu A, Dumitrascu D. 2023. Cognitive crescendo: how music shapes the brain’s structure and function. Brain Sciences 13(10): 1390.
Wahyuni S, Badriah B, Cahyati Y. 2021. Effect murottal therapy on blood pressure of pregnant women with hypertension. Journal of Nursing Care 4(1): 277-284.
Wang J, Wang J, Wang Y, Chai Y, Li H, Miao D, Liu H, Li J, Bao J. 2023. Music with different tones affects the development of brain nerves in mice in early life through BDNF and its downstream pathways. International Journal of Molecular Sciences 24(9): 8119
Yani AP, Joewono HT, Widjiati. 2021. Effect murottal sound stimulation during pregnancy on the number of neuron cells of cerebrum and cerebellum of the newborn Rattus norvegicus. Indian Journal Of Forensic Medicine & Toxicology 15(4): 845-851.
Published
2025-01-05
How to Cite
ARSIKA, Dwi Yulia Eva; SUARNI, Ni Made Rai; SUASKARA, Ida Bagus Made.
Pemberian musik klasik, musik rock, dan murottal Al-Qur’an pada induk bunting terhadap perkembangan cerebrum fetus mencit (Mus musculus).
Jurnal Biologi Udayana, [S.l.], v. 28, n. 2, p. 253-264, jan. 2025.
ISSN 2599-2856.
Available at: <https://ojs.unud.ac.id/index.php/bio/article/view/122689>. Date accessed: 08 jan. 2025.
doi: https://doi.org/10.24843/JBIOUNUD.2024.v28.i02.p07.
Section
Articles
