STRUKTUR HATI MENCIT (Mus musculus L.) SETELAH PEMBERIAN EKSTRAK DAUN KALIANDRA MERAH (Calliandra calothyrsus Meissn.)

Abstract

This research aims to determine the effect red calliandra leaf extract on weight, anatomy and
histology of male mice liver. Treatment was administered orally with varying doses (2, 4, 6
mg/ kg). Control grups was given 0,9% NaCl. This study used a completely randomized
design (CRD), consisting of 12 groups with three replications. Histological observations
showed that red calliandra leaf extract significantly affected the damage of male mice liver.
Damage level of nucleus pyknotic and fatty degeneration increased in line with the increasing
doses in treatment for 7 and 21 days, as well as the dilation of central venous in treatment for
7 days. The damage increase in line with the leght of treatment in the fatty degeneration (dose
2 mg/kg bw), nuclues pyknotic (doses 2 and 6 mg/kg bw), infiltration of inflammatory cells
(dose 4 mg/kg bw), sinusoid congestion (doses 2, 4 and 6 mg/kg bw), and central venous
dilatation (dose 2 and 4 mg/ kg bw).
Keywords : Red calliandra, male mice, liver histology