RELATIONSHIP OF URINARY C-TERMINAL TELOPEPTIDE COLLAGEN TYPE-II (CTX-II) LEVEL WITH THE DEGREE OF JOINT DAMAGE IN PATIENTS WITH KNEE OSTEOARTHITIS

  • Kusworini Handono
  • Farida **
  • BP Putra Suryana
  • Enny Listyawati

Abstract

Radiography of the knee is used to confirm the diagnosis and classification of knee OA severity. Urinary CTX- II  is a biochemical marker for assessing cartilage degradation of knee OA. This research aimed to analyze the correlation between the level of urinary CTX-II  and the radiographic severity of knee OA. Research was conducted in 40 patients with knee OA ( ACR criteria ) and 40 age and sex matched healthy controls. Wheight bearing anteroposterior and lateral semiflexed radiographs were taken of both knee. The patients were stratified based on the Kellgreen-Lawrence (K-L) score. Urinary CTX-II level was measured using ELISA competitive method. Correlation between urinary CTX-II level and radiographic knee OA severity was analyzed with Spearman Correlation. Statistical significance level at P < 0.05. Mean urinary CTX-II level was significantly higher in patients with OA compared with healthy controls (447.7( SB 316.39) ng/ml vs

289(SB 168.01) ng/mmol respectively, P = 0.023). There was a significant difference between urinary CTX-II level in patients with  grade ? 2 K-L knee OA compared with patients with grade > 2 K-L (240.35 (SB 88.90) ng/mmol vs 728.24 (SB 295.15) ng/mmol respectively; P < 0.001). The urinary CTX-II level was significantly associated with the degree of joint lesion in patients with OA (r = 0.734; P = 0.0001). Urinary level of CTX-II is strongly associated with the degree of radiographic joint lesion of OA

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Author Biographies

Kusworini Handono
Departemen Patologi Klinik Fakultas Kedokteran Universitas Braw?aya/Rumah Sakit Dr Saiful Anwar, Malang
Farida **
Departemen Patologi Klinik Fakultas Kedokteran Universitas Braw?aya/Rumah Sakit Dr Saiful Anwar, Malang
BP Putra Suryana
Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Braw?aya/Rumah Sakit Dr Saiful Anwar, Malang
Enny Listyawati
Departemen Radiologi Fakultas Kedokteran Universitas Braw?aya/Rumah Sakit Dr Saiful Anwar, Malang
How to Cite
HANDONO, Kusworini et al. RELATIONSHIP OF URINARY C-TERMINAL TELOPEPTIDE COLLAGEN TYPE-II (CTX-II) LEVEL WITH THE DEGREE OF JOINT DAMAGE IN PATIENTS WITH KNEE OSTEOARTHITIS. Medicina, [S.l.], v. 43, n. 3, apr. 2013. ISSN 2540-8321. Available at: <https://ojs.unud.ac.id/index.php/medicina/article/view/5065>. Date accessed: 29 mar. 2024.

Keywords

knee osteoarthritis, urinary CTX-II level, degree of joint lesion