BERBAGAI WAKTU PENYIMPANAN SECARA SPEKTROFOTOMETRI UV-VIS

  • Dewa Ayu Ika Pramitha
  • Ni Made Suaniti
  • I Wayan Suarsa

Abstract

This paper describes the determination of lamivudine content in pulveres by UV-Vis spectrophotometry. The purpose of this study was to determine the stability of lamivudine in various storage times. In this study, the validation of the method of the determination of lamivudine standard was also investigated with the following results: the linear regression equation y = 0.045x - 0.005 with correlation coefficient (r2) of 0.9998. Furthermore the detection limits obtained was of 0.46 µg/mL, quantitation limit of 1.53 µg/mL, the coefficient of variation of 0.23%, accuracy of 3.59%, and the recovery was of 96.41%. The stability of lamivudine in the samples decreased during the observation period i.e. 0, 7, 14, 21, and 28 days, during which the contents of lamivudine obtained were 87.46%, 86.22%, 84.44%; 76, 87%, 79.38%, respectively.

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Author Biographies

Dewa Ayu Ika Pramitha
Jurusan Kimia FMIPA Universitas Udayana, Bukit Jimbaran
Ni Made Suaniti
Jurusan Kimia FMIPA Universitas Udayana, Bukit Jimbaran
I Wayan Suarsa
Jurusan Kimia FMIPA Universitas Udayana, Bukit Jimbaran
Published
2014-01-01
How to Cite
IKA PRAMITHA, Dewa Ayu; SUANITI, Ni Made; SUARSA, I Wayan. BERBAGAI WAKTU PENYIMPANAN SECARA SPEKTROFOTOMETRI UV-VIS. Jurnal Kimia (Journal of Chemistry), [S.l.], jan. 2014. ISSN 2599-2740. Available at: <https://ojs.unud.ac.id/index.php/jchem/article/view/9748>. Date accessed: 28 mar. 2024. doi: https://doi.org/10.24843/JCHEM.2014.v08.i01.p10.
Section
Articles

Keywords

lamivudine, stability, pulveres, UV-Vis spectrofotomety

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