Faktor yang Mempengaruhi Perilaku dan Persepsi Dokter Hewan Bali Terhadap Penggunaan Antimikroba dan Resistensi Antimikroba
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https://doi.org/10.24843/bulvet.2022.v14.i06.p13
Abstrak
Resistensi antimikroba (AMR) adalah kemampuan bakteri untuk menahan efek obat, sehingga bakteri tidak mati setelah pemberian antimikroba dan fungsi obat tersebut tidak berkerja sama sekali. Kejadian ini diakibatkan oleh penggunaan antimikroba yang tidak terkontrol yang mampu menimbulkan krisis global pada kesehatan manusia dan hewan di masa depan. Penelitian ini bertujuan untuk mengetahui faktor yang mempengaruhi perilaku dan persepsi dokter hewan di Provinsi Bali terhadap penggunaan antimikroba dan resistensi antimikroba. Sebanyak 204 dokter hewan digunakan sebagai sampel penelitian dengan cara survei memakai sistem Likert dan kemudian hasil perbedaan tanggapan dokter hewan terhadap frekuensi peresepan dianalisis dengan Kruskal-Wallis. Hasil penelitian menunjukkan antimikroba diberikan ke separuh pasien yang ditangani tiap minggunya, dan faktor yang mempengaruhi pemberian antimikroba adalah riwayat penggunaan antimikroba, tingkat keamanannya, pengalaman, potensi, efek samping, dan resiko meningkatnya resistensi antimikroba. Biaya uji kultur dan harga antimikroba menjadi hambatan terbesar bagi dokter hewan praktisi hewan kecil tetapi tidak bagi dokter hewan praktisi hewan ternak. Seluruh responden mengakui bahwa sebagian besar sumber informasi mengenai AMR mudah didapatkan serta berguna bagi mereka. Kelompok dokter hewan praktisi hewan kecil dan praktisi hewan ternak sepakat bahwa AMR merupakan ancaman bersama yang serius di masa mendatang. Studi ini memberikan wawasan penting mengenai penerapan tindakan medis veteriner yang di Provinsi Bali dan kelak menjadi acuan dalam meningkatkan regulasi pengawasan terhadap penggunaan antimikroba.
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Referensi
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Beco L, Guaguere E, Mendez CL, Noli C, Nuttall T, Vroom M. 2013. Suggested guidelines for using systemic antimicrobials in bacterial skin infections (2): antimicrobial choice, treatment regimens and compliance. Vet. Rec. 172: 156–160.
Bhaskara IBM, Budiasa K, Gelgel KTP. 2012. Uji kepekaan escherichia coli sebagai penyebab kolibasilosis pada babi muda terhadap antibiotika oksitetrasiklin, streptomisin, kanamisin dan gentamisin. Indon. Med. Vet. 1(2): 186-201.
Buckland EL, O’Neill D, Summers J, Mateus A, Church D, Redmond L, Brodbelt D. 2016. Characterisation of antimicrobial usage in cats and dogs attending UK primary care companion animal veterinary practices. Vet. Rec. 179: 489.
Butaye P, Devriese LA, Haesebrouck F. 2003. Antimicrobial growth promoters used in animal feed: effects of less well-known antibiotics on gram-positive bacteria. Clin. Microbiol. Rev. 16(2): 175–188.
Coyne LA, Latham SM, Williams NJ, Dawson S, Donald IJ, Pearson RB. 2016. Understanding the culture of antimicrobial prescribing in agriculture: a qualitative study of UK pig veterinary surgeons. J. Antimicrob. Chemother. 71: 3300–3312.
De Briyne N, Atkinson J, Pokludova L, Borriello SP, Price S. 2013. Factors influencing antibiotic prescribing habits and use of sensitivity testing amongst veterinarians in Europe. Vet. Rec. 173: 475.
Economou V, Gousia P. 2015. Agriculture and food animals as a source of antimicrobial-resistant bacteria. Infect. Drug Resist. 8: 49–61.
Founou RC, Founou LL, Essack SY. 2017. Clinical and economic impact of antibiotic resistance in developing countries: a systematic review and meta-analysis. PLoS One. 12: e0189621.
Hardefeldt LY, Browning GF, Thursky K, Gilkerson JR, Billman-Jacobe H, Stevenson MA, Bailey KE. 2017. Antimicrobials used for surgical prophylaxis by companion animal veterinarians in Australia. Vet. Microbiol. 203: 301–307.
Hardefeldt LY, Gilkerson JR, Billman-Jacobe H, Stevenson MA, Thursky K. 2018. Barriers to and enablers of implementing antimicrobial stewardship programs in veterinary practices. J. Vet. Internal Med. 32: 1092–1099.
Kuzi S, Blum S, Kahane N, Adler A, Hussein O, Segev G. 2016. Multidrug resistant Acinetobacter calcoaceticus – Acinetobacter baumannii complex infection outbreak in dogs and cats in a veterinary hospital. J. Small Anim. Pract. 57(11): 617-625.
Marshall BM, Levy SB. 2011. Food animals and antimicrobials: Impacts on human health. Clin. Microbiol. Rev. 24(4): 718-733.
Masyeni S, Sukmawati H, Siskayani AS, Dharmayanti S, Sari K. 2018. Antimicrobial susceptibility pattern of pathogens isolated from various specimens in denpasar-bali: a two years retrospective study. Biomed. Pharmacol. J. 11(1): 493-502.
Mustika OC, Pinatih KJP, Suardana IW. 2015. Antibiotic resistance profiles of escherichia coli o157:h7 in cattle at South-Kuta, Badung Regency, Bali, Indonesia. Glob. Vet. 15(5): 480-484.
Norris JM, Zhuo A, Govendir M, Rowbotham SJ, Labbate M, Degeling C, Gilbert GL, Dominey-Howes D, Wardet MP 2019. Correction: Factors influencing the behaviour and perceptions of Australian veterinarians towards antibiotic use and antimicrobial resistance. PLOS ONE. 14(10): e0224844.
Postma M, Speksnijder DC, Jaarsma AD, Verheij TJ, Wagenaar JA, Dewulf J. 2016. Opinions of veterinarians on antimicrobial use in farm animals in Flanders and the Netherlands. Vet. Rec. 179: 68.
Prasetya RR, Poetranto ED, Handijatno D. 2017. Identifikasi gen aerolysin dan sensitivitas antibiotik aeromonas hydrophila penyebab kematian tukik (lepidochelys olivacea) di Pulau Serangan, Bali. J. Vet. 18(2): 201-206.
Saputra S, Jordan D, Mitchell T, Wong HS, Abraham RJ, Kidsley A, Turnidge J, Trott DJ, Abraham S. 2017. Antimicrobial resistance in clinical Escherichia coli isolated from companion animals in Australia. Vet. Microbiol. 211: 43–50.
Shrestha P, Cooper BS, Coast J. 2018. Enumerating the economic cost of antimicrobial resistance per antibiotic consumed to inform the evaluation of interventions affecting their use. Antimicrob. Res. Infect. Control. 17(1): 98.
Singleton DA, Sanchez-Vizcaino F, Dawson S, Jones PH, Noble PJM, Pinchbeck GL, Williams NJ, Radford AD. 2017. Patterns of antimicrobial agent prescription in a sentinel population of canine and feline veterinary practices in the United Kingdom. Vet. J. 224: 18–24.
Smith M, King C, Davis M, Dickson A, Park J. 2018. Pet owner and vet interactions: exploring the drivers of AMR. Antimicrob. Resist. Infect. Control. 7(46): 1-9.
Speksnijder DC, Jaarsma DAC, Verheij TJM, Wagenaar JA. 2015. Attitudes and perceptions of Dutch veterinarians on their role in the reduction of antimicrobial use in farm animals. Prev. Vet. Med. 121: 365–373.
Suharsa IWA, Suarjana, IGK, Gelgel KTP. 2015. Pola kepekaan e coli yang diisolasi dari feses broiler penderita diare terhadap sulfametoksazol, ampisilin dan oksitetrasiklin. Bul. Vet. Udayana. 7(2): 101-106.
Tang KL, Caffrey NP, Nóbrega DB, Cork SC, Ronksley PE, Barkema HW, Polachek AJ, Ganshorn H, Sharma N, Kellner JD, Ghali WA 2017. Restricting the use of antibiotics in food-producing animals and its associations with antibiotikaresistance in food-producing animals and human beings: a systematic review and meta-analysis. The Lancet Planet. Health. 1: e316–e327.
Van Breda LK, Dhungyel OP, Ward MP. 2018. Antibiotic resistant E. coli in southeastern Australian pig herds and implications for surveillance. Zoon. Pub. Health. 65: e1–e7.
Walther B, Tedin K, Lübke-Becker A. 2017. Multidrug-resistant opportunistic pathogens challenging veterinary infection control. Vet. Microbiol. 200: 71-78.
Weese JS, Blondeau J, Boothe D, Guardabassi LG, Gumley N, Papich M, Jessen LR, Lappin M, Rankin S, Westropp, Skyes J. 2019. International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats. The Vet. J. 247: 8–25.
Beco L, Guaguere E, Mendez CL, Noli C, Nuttall T, Vroom M. 2013. Suggested guidelines for using systemic antimicrobials in bacterial skin infections (2): antimicrobial choice, treatment regimens and compliance. Vet. Rec. 172: 156–160.
Bhaskara IBM, Budiasa K, Gelgel KTP. 2012. Uji kepekaan escherichia coli sebagai penyebab kolibasilosis pada babi muda terhadap antibiotika oksitetrasiklin, streptomisin, kanamisin dan gentamisin. Indon. Med. Vet. 1(2): 186-201.
Buckland EL, O’Neill D, Summers J, Mateus A, Church D, Redmond L, Brodbelt D. 2016. Characterisation of antimicrobial usage in cats and dogs attending UK primary care companion animal veterinary practices. Vet. Rec. 179: 489.
Butaye P, Devriese LA, Haesebrouck F. 2003. Antimicrobial growth promoters used in animal feed: effects of less well-known antibiotics on gram-positive bacteria. Clin. Microbiol. Rev. 16(2): 175–188.
Coyne LA, Latham SM, Williams NJ, Dawson S, Donald IJ, Pearson RB. 2016. Understanding the culture of antimicrobial prescribing in agriculture: a qualitative study of UK pig veterinary surgeons. J. Antimicrob. Chemother. 71: 3300–3312.
De Briyne N, Atkinson J, Pokludova L, Borriello SP, Price S. 2013. Factors influencing antibiotic prescribing habits and use of sensitivity testing amongst veterinarians in Europe. Vet. Rec. 173: 475.
Economou V, Gousia P. 2015. Agriculture and food animals as a source of antimicrobial-resistant bacteria. Infect. Drug Resist. 8: 49–61.
Founou RC, Founou LL, Essack SY. 2017. Clinical and economic impact of antibiotic resistance in developing countries: a systematic review and meta-analysis. PLoS One. 12: e0189621.
Hardefeldt LY, Browning GF, Thursky K, Gilkerson JR, Billman-Jacobe H, Stevenson MA, Bailey KE. 2017. Antimicrobials used for surgical prophylaxis by companion animal veterinarians in Australia. Vet. Microbiol. 203: 301–307.
Hardefeldt LY, Gilkerson JR, Billman-Jacobe H, Stevenson MA, Thursky K. 2018. Barriers to and enablers of implementing antimicrobial stewardship programs in veterinary practices. J. Vet. Internal Med. 32: 1092–1099.
Kuzi S, Blum S, Kahane N, Adler A, Hussein O, Segev G. 2016. Multidrug resistant Acinetobacter calcoaceticus – Acinetobacter baumannii complex infection outbreak in dogs and cats in a veterinary hospital. J. Small Anim. Pract. 57(11): 617-625.
Marshall BM, Levy SB. 2011. Food animals and antimicrobials: Impacts on human health. Clin. Microbiol. Rev. 24(4): 718-733.
Masyeni S, Sukmawati H, Siskayani AS, Dharmayanti S, Sari K. 2018. Antimicrobial susceptibility pattern of pathogens isolated from various specimens in denpasar-bali: a two years retrospective study. Biomed. Pharmacol. J. 11(1): 493-502.
Mustika OC, Pinatih KJP, Suardana IW. 2015. Antibiotic resistance profiles of escherichia coli o157:h7 in cattle at South-Kuta, Badung Regency, Bali, Indonesia. Glob. Vet. 15(5): 480-484.
Norris JM, Zhuo A, Govendir M, Rowbotham SJ, Labbate M, Degeling C, Gilbert GL, Dominey-Howes D, Wardet MP 2019. Correction: Factors influencing the behaviour and perceptions of Australian veterinarians towards antibiotic use and antimicrobial resistance. PLOS ONE. 14(10): e0224844.
Postma M, Speksnijder DC, Jaarsma AD, Verheij TJ, Wagenaar JA, Dewulf J. 2016. Opinions of veterinarians on antimicrobial use in farm animals in Flanders and the Netherlands. Vet. Rec. 179: 68.
Prasetya RR, Poetranto ED, Handijatno D. 2017. Identifikasi gen aerolysin dan sensitivitas antibiotik aeromonas hydrophila penyebab kematian tukik (lepidochelys olivacea) di Pulau Serangan, Bali. J. Vet. 18(2): 201-206.
Saputra S, Jordan D, Mitchell T, Wong HS, Abraham RJ, Kidsley A, Turnidge J, Trott DJ, Abraham S. 2017. Antimicrobial resistance in clinical Escherichia coli isolated from companion animals in Australia. Vet. Microbiol. 211: 43–50.
Shrestha P, Cooper BS, Coast J. 2018. Enumerating the economic cost of antimicrobial resistance per antibiotic consumed to inform the evaluation of interventions affecting their use. Antimicrob. Res. Infect. Control. 17(1): 98.
Singleton DA, Sanchez-Vizcaino F, Dawson S, Jones PH, Noble PJM, Pinchbeck GL, Williams NJ, Radford AD. 2017. Patterns of antimicrobial agent prescription in a sentinel population of canine and feline veterinary practices in the United Kingdom. Vet. J. 224: 18–24.
Smith M, King C, Davis M, Dickson A, Park J. 2018. Pet owner and vet interactions: exploring the drivers of AMR. Antimicrob. Resist. Infect. Control. 7(46): 1-9.
Speksnijder DC, Jaarsma DAC, Verheij TJM, Wagenaar JA. 2015. Attitudes and perceptions of Dutch veterinarians on their role in the reduction of antimicrobial use in farm animals. Prev. Vet. Med. 121: 365–373.
Suharsa IWA, Suarjana, IGK, Gelgel KTP. 2015. Pola kepekaan e coli yang diisolasi dari feses broiler penderita diare terhadap sulfametoksazol, ampisilin dan oksitetrasiklin. Bul. Vet. Udayana. 7(2): 101-106.
Tang KL, Caffrey NP, Nóbrega DB, Cork SC, Ronksley PE, Barkema HW, Polachek AJ, Ganshorn H, Sharma N, Kellner JD, Ghali WA 2017. Restricting the use of antibiotics in food-producing animals and its associations with antibiotikaresistance in food-producing animals and human beings: a systematic review and meta-analysis. The Lancet Planet. Health. 1: e316–e327.
Van Breda LK, Dhungyel OP, Ward MP. 2018. Antibiotic resistant E. coli in southeastern Australian pig herds and implications for surveillance. Zoon. Pub. Health. 65: e1–e7.
Walther B, Tedin K, Lübke-Becker A. 2017. Multidrug-resistant opportunistic pathogens challenging veterinary infection control. Vet. Microbiol. 200: 71-78.
Weese JS, Blondeau J, Boothe D, Guardabassi LG, Gumley N, Papich M, Jessen LR, Lappin M, Rankin S, Westropp, Skyes J. 2019. International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats. The Vet. J. 247: 8–25.
Diterbitkan
2022-04-04
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SITANGGANG, Vera Paulina; BESUNG, I Nengah Kerta; MAHATMI, Hapsari.
Faktor yang Mempengaruhi Perilaku dan Persepsi Dokter Hewan Bali Terhadap Penggunaan Antimikroba dan Resistensi Antimikroba.
Buletin Veteriner Udayana, [S.l.], p. 705-713, apr. 2022.
ISSN 2477-2712.
Tersedia pada: <http://ojs.unud.ac.id/index.php/buletinvet/article/view/84668>. Tanggal Akses: 20 feb. 2026
doi: https://doi.org/10.24843/bulvet.2022.v14.i06.p13.
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