COMPARISON OF GLOMERULAR FILTRATION RATE AND CHRONIC KIDNEY DISEASE PREVALENCE USING COCKCROFT-GAULT(C-G) AND MODIFICATION OF DIET IN RENAL DISEASE (MDRD FOR CHINESE FORMULA AMONG BALINESE POPULATION

Abstract

Some community based study to determine the prevalence of chronic kidney disease has been conducted.It is reported that a reasonable rate of prevalence of CKD if calculated with different formula (either C-Gor MDRD). This  study  is aiming  to  compare estimated GFR and CKD prevalence determined byeitherC-G or MDRD  and the new Chinese modified MDRD formulaThis  study  analyzed  4528  subjects  from  7  areas  in Bali  Islands  including  219(4.8%)    subjects  inSembiran, 302 (6.7%), Denpasar 302 (6.7%), Nusa Ceningan 305 (6.7%), Legian282 (6.2%)  Blahbatuh3038(67.1%), Tenganan,  81(1.8%),  and  in Ubud  301(6.6%),  consisted  2217  (49%) males  and  2311(51%) females. It is found that there were a substantial differences and stepwise increase (79, 83, 86,and105 mL/min/  1.73 m2),  consecutively  of mean  of  estimated-GFR  if  calculated  by C-G, MDRD,MDRD for Chinese (if  non-Chinese), and MDRD for Chinese (if Chinese) formula. It was also foundthat differences of prevalence rate CKD using different formulas.  More than twenty percent (20.6%) ofCKD defined by estimated-GFR of 59 to 30 ml/min per 1.73m2 when were calculated by C-G,  and 6.9and 6.8 percent if were calculated by MDRD and  MDRD for Chinese (if  non-Chinese), consecutively,however, it is much lower (2.2%) using MDRD formula for Chinese (if Chinese).In conclusion, this study shows difference inmeanvalues of e GFR and  prevalence of CKD if calculatedusing  different  formulas. A  valid  formula  is  needed  for  specific  Indonesian  people.  [MEDICINA2014;45:151-155].