THE THE ACTIVITIES OF ALANINE AMINOTRANSFERASE AND ASPARTATE AMINOTRANSFERASE ENZYMES IN MALE WHITE RATS TREATED WITH EXTRACT ARECA NUT TREATMENT
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Abstract
Areca nut is a plant of Arecaceae family, known as herbal medicine and useful as an anthelmetic treatment. The aim of this research was to determine hepar toxicity of the Areca nut extracts given to male white rats by measuring ALT and AST. The doses of extracts were 100 mg/kg, 200 mg/kg, and 400 mg/kg body weight respectively. Data were analyzed by analysis of variance. The results showed that no significant effect of ALT and AST enzymes found in the treatment groups. Betel nut extract in those concentration was not toxic in the male white rats.
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References
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Boucher BJ, Mannan N. 2002. Metabolic effects of the compsumtion of Areca catechu. University of London. J Addiction Alcohol Drugs 7: 103-110.
Cave M, Appana S, Patel M, Falker KC, Clain MC, Brock G. 2010. Polychlorinated biphenyls, lead and mercury are associated with liver disease in American adult: NHANES 2003-2004. Environmental Health Perspectives 118(12): 1735-1742
Fine AM. 2000, Oligomeric Proanthocyanidin Complexes: History, Structure, and Phytopharmaceutical Applications. Altern Med Rev 5(2):144-151.
Edy M, Ratna AS, Sri H, Fitria R. 2008. Ethanolic extract of Areca catechu seeds inhibit proliferation and induce apoptosis on MCF-7 cells. J Medicine Indonesia 19: 12-19.
Hasnawati M. 2006. Pengaruh Konsentrasi dan Lama Perendaman Dalam Larutan Serbuk Biji Pinang (Areca Catechu L.) terhadap Mortalitas Cacing Hati Sapi (Fasciola Hepatica L.) Secara In Vitro. J Medicine Indonesia 10: 11-18.
Heegazy AMS, Fouad UA. 2015. Evaluation of Lead Hepatotoxycity: Histological, Histochemical and Ultrastructural Study. Forensic Med Anat Res 2: 70-79.
Hozaimah S. 2007. Kadar SGOT dan SGPT pada Tikus Putih (Rattus novegicus) Akibat konsumsi Minyak Jelantah Bermerek dan Tidak Bermerek dari Beberapa Kali Penggorengan. J Farmasi 5: 10-19.
Kendran AAS, Damriyasa IM, Dharmawan NS, Ardana IBK, Anggreni LD. 2012. Profil Kimia Klinik Darah Sapi Bali. J Veteriner 13(4): 410-415
Murry LR 2003. Primary (AL) Hepatic Amyloidosis: Clinical Features. J. Medicine 82(5): 251-258
Nuri. 2007. Pengembangan Formula Sediaan Fitoterapeutika Tersetandar untuk Terapi dari Tanaman Obat di Kabupaten Jember. Lembaga Penelitian Universitas Jember.
Rosandi H. 2008. Pengaruh Pemberian Ekstrak Dauh Teh Hijau (Camellia sinensis) terhadap Kadar SGPT Tikus Putih (Rattus norvegicus) yang Diinduksi Isonazid. Universitas Sebelas Maret. Surakarta.
Saroni A. 2005. Spesifikasi Simplisia dan Ekstrak Etanol Biji Pinang (Areca catechu L.) Asal Tawangmangu serta Toksisitas Akut dan Khasiat Hemostatiknya pada Hewan Coba. J Farmasi Indonesia Jakarta 5: 1-9
Sampurna IP. Nindhia TS. 2008. Analisis Data dengan SPSS dalam Rancangan Percobaan. Denpasar: Udayana University Press, Universitas Udayana.
Sutrisno RB. 2000. Ihtisar Farmakognosi. Jurnal Farmasi Indonesia Pharmascience Pacific. Jakarta. Vol: IV (15)
Wibowo AW, Masclachch L, Bijanti. 2007. Pengaruh Pemberian Perasaan Buah Mengkudu (Morinda citrifolia) Terhadap Kadar SGOT dan SGPT Tikus Putih (Rattusnorvegicus) dengan Diet Tinggi Lemak. J Veterineria Medika 1:1-5
Zhang X, Wu J, Han Z, Mei WL, and Dai H. 2010. Antioxidant and Cytotoxic Phenilic Compounds of Areca Nut (Areca catechu). J Chem Res 26(1):161-164.
Published
2017-08-29
How to Cite
KENDRAN, Anak Agung Sagung; ARJANA, Anak Agung Gde; PRADNYANTARI, Anak Agung Sagung Istri.
THE THE ACTIVITIES OF ALANINE AMINOTRANSFERASE AND ASPARTATE AMINOTRANSFERASE ENZYMES IN MALE WHITE RATS TREATED WITH EXTRACT ARECA NUT TREATMENT.
Buletin Veteriner Udayana, [S.l.], p. 132-138, aug. 2017.
ISSN 2477-2712.
Available at: <https://ojs.unud.ac.id/index.php/buletinvet/article/view/31381>. Date accessed: 22 nov. 2024.
Section
Articles
