DIFFERENCE OF SGOT AND SGPT LEVEL IN STADIUM IIB-IIIB SQUAMOUS CELL CERVICAL CANCER PATIENTS BEFORE AND AFTER CHEMOTHERAPY AT SANGLAH HOSPITAL DENPASAR

  • R. Noviyani

Abstract

Objective:Cervical cancer became Indonesia’s highest prevalent gynecological cancer in 2013 and the highest


prevalent gynecological cancer at Sanglah Hospital.Paclitaxel Carboplatin is one of the regimens used for


cervical cancer treatment at Sanglah Hospital, Denpasar. Aside of providing therapeutic effect, this regimen also


causes hepatotoxicity. This research was trying to determine the toxic effect of Paclitaxel Carboplatin towards


liver function based on the difference of SGOT and SGPT levels before chemotherapy cycle I and after


chemotherapy cycle VI. Method:This wasa prospective observational research with a study case method


conducted from January 2017 until June 2017 at Obstetric Polyclinic of Sanglah Hospital, Denpasar.Samples’


SGOT and SGPT level before and after chemotherapy I and VI were recorded and were then analysed with


Shapiro-Wilk normality test. If the data were distributed normally, they would undergo tpaired test and


Wilcoxon test at 95% confidence level if they were not distributed normally. Results: Tenpatients fulfilled the


research criteria. There was a meaningless increase for SGOT level (p=0.575) along with a meaningless increase


for SGPT level (p=0.074) before and after Paclitaxel Carboplatin chemotherapy cycle I and VI


respectively.Conclusion: Research of toxic effect from Paclitaxel Carboplatin chemotherapy in 10 squamous


cell cervical cancer patients showed a meaningless difference of both SGOT and SGPT level with the value of


p>0.05 in stadium IIB-IIIB squamous cell cervical cancer patients before and after Paclitaxel Carboplatin


chemotherapy cycle I and VI respectively.

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Published
2018-02-02
How to Cite
NOVIYANI, R.. DIFFERENCE OF SGOT AND SGPT LEVEL IN STADIUM IIB-IIIB SQUAMOUS CELL CERVICAL CANCER PATIENTS BEFORE AND AFTER CHEMOTHERAPY AT SANGLAH HOSPITAL DENPASAR. Journal of Health Sciences and Medicine, [S.l.], v. 2, n. 1, p. 5, feb. 2018. ISSN 2622-0555. Available at: <https://ojs.unud.ac.id/index.php/JHSM/article/view/47791>. Date accessed: 13 july 2020.