ALDEHID DEHIDROGENASE DALAM TIKUS WISTAR SEBAGAI BIOMARKER AWAL KONSUMSI ALKOHOL SECARA AKUT

  • NI MADE SUANITI
  • A.A.GEDE SUDEWA DJELANTIK
  • I KETUT SUASTIKA
  • I NYOMAN MANTIK ASTAWA

Abstract

Research on oral consumption of alcohol on rat Wistar was done to examine level of aldehyde dehydrogenase (ALDH) in rat serum. The research design was true randomized experimental post test only control group design. This research was conducted in two stages: first, eight rats were treated with 5% alcohol continuously for 1 week and as control aquadest was given to eight rats. The second stage was determination of ALDH levels. Wistar rat serum were taken after 6 hours and 24 hours of 5% alcohol consumption. The levels of ALDH increase by 117.15% after 6 hours of 5% alcohol consumption, while after 24 hours the levels of ALDH increase by 108.14%. ALDH levels in serum rat Wistar can be used as early biomarker of acute alcohol consumption.

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Author Biographies

NI MADE SUANITI
Lab. Kimia Analitik-Forensik Jurusan Kimia FMIPA UNUD, Kampus Bukit Jimbaran, Badung.
A.A.GEDE SUDEWA DJELANTIK
Fakultas Kedokteran, Universitas Udayana
I KETUT SUASTIKA
Fakultas Kedokteran, Universitas Udayana
I NYOMAN MANTIK ASTAWA
Fakultas Kedokteran Hewan, Universitas Udayana
Published
2011-06-01
How to Cite
SUANITI, NI MADE et al. ALDEHID DEHIDROGENASE DALAM TIKUS WISTAR SEBAGAI BIOMARKER AWAL KONSUMSI ALKOHOL SECARA AKUT. Jurnal Biologi Udayana, [S.l.], v. 15, n. 1, p. -, june 2011. ISSN 2599-2856. Available at: <https://ojs.unud.ac.id/index.php/BIO/article/view/599>. Date accessed: 26 may 2020.

Keywords

ALDH; histopathology; rat Wistar; biomarker; alcohol