Efek ekstrak etanol kedelai hitam (Glycine soja) terhadap ketebalan dermis mencit (Mus musculus L.) pasca unilateral ovariektomi

Abstract

Estrogen is a steroid hormone produced by the ovaries. Estrogen is a hormone that triggers collagen
synthesis by fibroblast.Collagen has affects for thickness of dermis.Estrogen deficiency can lead disruption
collagen synthesis, so has an impact on decline dermis thickness. Unilateral ovariectomy is the act of
removal of one ovary in the female reproductive system and is a model for estrogen deficiency. The
condition of estrogen deficiency can be overcome by giving phytoestrogens. Black soybean seed is one of
phytoestrogens source. The purpose of this study was to determine the effect of black soybean extract after
ovariectomy on increasing on dermis thickness (Mus musculus L.). The dosage of black soybean ethanol
extract used was 0.31 g / ml / day and 0.63 g / ml / day administered orally (gavage) for 20 days. The results
showed a dose of 0.31 g / ml / day may and 0.63 g / ml / day increase dermis thickness of mice.