Terapi Sel Punca Mesenkimal Sumsum Tulang Tikus dalam Meregenerasi Sel Sitotrofoblas Nekrosis yang Dipapar Carbon Black (RAT BONE MARROW MESENCHYMAL STEM CELL THERAPY IN REGENERATING NECROTIC CYTOTROPHOBLAST CELL FOLLOWING EXPOSED TO CARBON BLACK)

  • Widjiati . Bagian Klinik Hewan, Fakultas Kedokteran Hewan, Universitas Udayana, Bali
  • Sri Pantja Madyawati
  • Rimayanti .
  • Agung Budianto Achmad

Abstract

The objective of this study is to find out the potency of Rat Bone Marrow Mesenchymal Stem Cell(RBMMSC) in regenerating necrotic cytotrophoblast cells of rats (Rattusnorvegicus) following exposure tocarbon black at day 6 of gestation at different time of exposure (6 days and 12 days). This study usedrandomized factorial design with two factors (gestation day and treatment). Forty-eight gravid femalerats were divided into six treatment groups i.e. (i) animals at day 6-11 gestation and not expose to carbonblack; (ii) 6-11 days gestation animals + 532mg/m3 carbon black for 4 hours; (iii) 6-11 days gestationanimals + 532mg/m3 carbon black for 4 hours +1x107/0.1ml RBMMSC intravenously; (iv) animals at day6-17 gestation and not expose to carbon black; (v) 6-17 days gestation animals + 532mg/m3 carbon blackfor 4 hours; (vi) 6-17 days gestation animals + 532mg/m3 carbon black for 4 hours +1x107/0.1ml RBMMSCintravenously, respectively. Data were analyzed using univariat analysis and analysis of variance. Theresults showed that there were no significance differences in regenerating necrotic cytotrophoblast betweenthe groups treated with RBMMSC and carbon black exposure. The results indicated that the stem celltherapy following exposure to carbon black was incapable in regenerating the necrotic cytotrophoblastcells.

Downloads

Download data is not yet available.
Published
2015-08-10
How to Cite
., Widjiati et al. Terapi Sel Punca Mesenkimal Sumsum Tulang Tikus dalam Meregenerasi Sel Sitotrofoblas Nekrosis yang Dipapar Carbon Black (RAT BONE MARROW MESENCHYMAL STEM CELL THERAPY IN REGENERATING NECROTIC CYTOTROPHOBLAST CELL FOLLOWING EXPOSED TO CARBON BLACK). Jurnal Veteriner, [S.l.], v. 16, n. 2, p. 265-273, aug. 2015. ISSN 2477-5665. Available at: <http://ojs.unud.ac.id/index.php/jvet/article/view/14619>. Date accessed: 27 sep. 2025.
Citation Formats
Issue
Vol 16 No 2 (2015)
Section
Articles

Keywords

carbon black, stem cell therapy, rat bone marrow, cytotrophoblast
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License
Warning: array_merge(): Argument #2 is not an array in /var/www/ojs.unud.ac.id_backup/lib/pkp/classes/core/PKPApplication.inc.php on line 578 Warning: Invalid argument supplied for foreach() in /var/www/ojs.unud.ac.id_backup/plugins/generic/recommendByAuthor/RecommendByAuthorPlugin.inc.php on line 114