High Interleukin-6 Level Increases Depression Risk on Geriatric Population in Denpasar, Bali-Indonesia

  • Cokorda Agung Wahyu Purnamasidhi Internal Medicine Department Medical Faculty Udayana University Denpasar, Bali, Indonesia
  • R.A. Tuty Kuswardhani Geriatric Division, Internal Medicine Department Medical Faculty Udayana University Denpasar, Bali, Indonesia

Abstract

Background: High interleukin-6 (IL-6) serum level was responsible in inflammatory regulation through the interaction within macrophage, glial melatonin production and regulation of methyl CpG- binding protein 2 (MeCP2) and influenced neuro-inflammation process, thus, it increased the risk of depression. The aim of this study was to determine whether high interleukin-6 serum level increased the risk of depression in geriatrics. Methods: A case control was performed as the design of this study. Geriatric populations with depression enrolled as the case group and without depression as control group. Assessment of IL-6 serum level was conducted by the patient’s venous blood. The IL-6 serum> 10 pg/ml was categorized as high. Results: In this study, 30 cases and 30 controls who met the criteria included as samples. There were 20 males (66.7%) and 10 females (33.3%). Factors associated with an increased risk of depression in geriatric were a high level of serum interleukin-6 (OR=3.60; CI95%: 1.22-10.64, p=0.018) and a marital status (OR=3.50; CI95%: 1.11- 1.02, p=0.028). High level of interleukin-6 was a significant and an independent risk factor of depression in geriatric (OR=3.60; CI95%: 1.22-10.64, p=0.021) in multivariate analysis. Conclusion: This study concluded that high IL- 6 serum level increased the risk of depression in geriatric.

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Author Biographies

Cokorda Agung Wahyu Purnamasidhi, Internal Medicine Department Medical Faculty Udayana University Denpasar, Bali, Indonesia
Internal Medicine Department Medical Faculty Udayana University Denpasar, Bali, Indonesia
R.A. Tuty Kuswardhani, Geriatric Division, Internal Medicine Department Medical Faculty Udayana University Denpasar, Bali, Indonesia
Geriatric Division, Internal Medicine Department Medical Faculty Udayana University Denpasar, Bali, Indonesia
Published
2016-09-15
How to Cite
PURNAMASIDHI, Cokorda Agung Wahyu; KUSWARDHANI, R.A. Tuty. High Interleukin-6 Level Increases Depression Risk on Geriatric Population in Denpasar, Bali-Indonesia. BALI MEDICAL JOURNAL, [S.l.], v. 5, n. 3, sep. 2016. ISSN 2302-2914. Available at: <http://ojs.unud.ac.id/index.php/bmj/article/view/23945>. Date accessed: 22 aug. 2025.
Citation Formats
Issue
Vol 5 No 3 (2016)
Section
Articles

Keywords

serum interleukin-6 level, risk, depression in geriatric
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